Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals

The combination of plasma tissue inhibitor of metalloproteinases-1 (1) and CEA has been shown to have utility in early detection of colorectal cancer (2). A prospective study was performed to validate previous findings. Individuals undergoing large bowel endoscopy were prospectively included (N=1965...

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Bibliographic Details
Published in:Anticancer research 2015-09, Vol.35 (9), p.4935-4941
Main Authors: Christensen, Ib Jarle, Brünner, Nils, Dowell, Barry, Davis, Gerard, Nielsen, Hans Jørgen, Newstead, Graham, King, Denis
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Carcinoembryonic Antigen - blood
Colorectal Neoplasms - blood
Colorectal Neoplasms - enzymology
Endoscopy
Female
Humans
Male
Middle Aged
Prospective Studies
Reproducibility of Results
ROC Curve
Tissue Inhibitor of Metalloproteinase-1 - blood
Young Adult
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Summary:The combination of plasma tissue inhibitor of metalloproteinases-1 (1) and CEA has been shown to have utility in early detection of colorectal cancer (2). A prospective study was performed to validate previous findings. Individuals undergoing large bowel endoscopy were prospectively included (N=1965). Baseline data and co-morbidity were recorded. The primary end-point was the detection of CRC. Plasma was obtained before endoscopy and TIMP-1 and CEA levels were determined using an automated analysis platform when all samples were collected. CRC was detected in 32 individuals, 24 with colonic cancer (CC) and 8 with rectal cancer (RC). Other findings were 265 with adenomas and 889 with non-neoplastic pathology. The biomarker levels were elevated in plasma from patients with CRC, but also from patients with various co-morbidities compared to individuals without any findings at endoscopy. Univariate analysis demonstrated that both markers were significant predictors of CRC. The odds ratios (OR) for an elevated TIMP-1 level for the detection of CRC was 6.2 [95% confidence interval (CI)=3.1-13.0, p
ISSN:1791-7530