Preparation and biodistribution of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99m as a potential brain receptor imaging agent

The goal of this study is to develop a novel brain receptor imaging agent. This study reports the synthesis, characterization and the biological evaluation of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99 m (99mTc-MP). The 99mTc-MP was obtained quickly (radiolabelli...

Full description

Saved in:
Bibliographic Details
Published in:European journal of medicinal chemistry 2015-06, Vol.97, p.280-288
Main Authors: Saied, Nadia Malek, Mejri, Najoua, Aissi, Radhia El, Benoist, Eric, Saidi, Mouldi
Format: Article
Language:English
Subjects:
1-(2-methoxyphenyl) piperazine
99mTc-tricarbonyl complex
Animals
Brain - diagnostic imaging
Brain - metabolism
Hippocampus - diagnostic imaging
Hippocampus - metabolism
Male
Organotechnetium Compounds - chemical synthesis
Organotechnetium Compounds - pharmacokinetics
Piperazines - chemical synthesis
Piperazines - pharmacokinetics
Radionuclide Imaging
Radiopharmaceuticals
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - pharmacokinetics
Rats
Rats, Wistar
Receptors, Serotonin - analysis
Tissue Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The goal of this study is to develop a novel brain receptor imaging agent. This study reports the synthesis, characterization and the biological evaluation of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99 m (99mTc-MP). The 99mTc-MP was obtained quickly (radiolabelling time 
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2015.05.014