Statin use and mortality in cancer patients: Systematic review and meta-analysis of observational studies

Highlights • 39 cohort and 2 case-control studies involving 990,649 participants are reached. • We evaluate study quality using the Newcastle–Ottawa Scale. • Statin use before or after cancer diagnosis improves survival of cancer patients. • The dose–response effects of postdiagnosis statin use on m...

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Bibliographic Details
Published in:Cancer treatment reviews 2015-06, Vol.41 (6), p.554-567
Main Authors: Zhong, Shanliang, Zhang, Xiaohui, Chen, Lin, Ma, Tengfei, Tang, Jinhai, Zhao, Jianhua
Format: Article
Language:English
Subjects:
Dose-Response Relationship, Drug
Female
Hematology, Oncology and Palliative Medicine
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Neoplasm
Neoplasms - mortality
Outcome
Prognosis
Survival
Tumor
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Summary:Highlights • 39 cohort and 2 case-control studies involving 990,649 participants are reached. • We evaluate study quality using the Newcastle–Ottawa Scale. • Statin use before or after cancer diagnosis improves survival of cancer patients. • The dose–response effects of postdiagnosis statin use on mortality is assessed.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2015.04.005