Primary mediastinal large B-cell lymphoma

Highlights • We discuss key clinicopathologic and genetic features of this lymphoma. • We discuss about the role of rituximab and PET scan. • We have presented data to support omission of mediastinal radiation in select patients. • Data on intensified chemotherapy alone such as DA-R-EPOCH is discuss...

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Bibliographic Details
Published in:Cancer treatment reviews 2015-06, Vol.41 (6), p.476-485
Main Authors: Bhatt, Vijaya Raj, Mourya, Rajesh, Shrestha, Runa, Armitage, James O
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chemotherapy
Female
Hematology, Oncology and Palliative Medicine
Humans
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - mortality
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Large B-Cell, Diffuse - therapy
Male
Mediastinal Neoplasms - diagnosis
Mediastinal Neoplasms - mortality
Mediastinal Neoplasms - pathology
Mediastinal Neoplasms - therapy
Mediastinal radiation
Neoplasm Staging
Positron emission tomography
Primary mediastinal large B-cell lymphoma
Rituximab
Salvage Therapy
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Summary:Highlights • We discuss key clinicopathologic and genetic features of this lymphoma. • We discuss about the role of rituximab and PET scan. • We have presented data to support omission of mediastinal radiation in select patients. • Data on intensified chemotherapy alone such as DA-R-EPOCH is discussed. • Promising targeted agents are briefly discussed.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2015.04.006