Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities

•A procedure for synchronized extraction and sulfation of polysaccharides being developed.•This one-pot process generates xylomannan sulfates of high sulfation degree.•These Scinaia hatei derived polysaccharides demonstrate significant antiHSV efficacy.•Sulfate content, molecular mass and glycosyl c...

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Bibliographic Details
Published in:Carbohydrate polymers 2015-10, Vol.131, p.315-321
Main Authors: Ray, Sayani, Pujol, Carlos A., Damonte, Elsa B., Ray, Bimalendu
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - pharmacology
Antiviral drug candidate
Cercopithecus aethiops
Cytotoxicity
Glycosides - chemistry
Herpesvirus 1, Human - drug effects
Molecular Weight
Oligosaccharides - isolation & purification
Oligosaccharides - pharmacology
Polysaccharide engineering
Rhodophyta - chemistry
Scinaia hatei
Spectroscopy, Fourier Transform Infrared
Sulfates - chemistry
Vero Cells
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Summary:•A procedure for synchronized extraction and sulfation of polysaccharides being developed.•This one-pot process generates xylomannan sulfates of high sulfation degree.•These Scinaia hatei derived polysaccharides demonstrate significant antiHSV efficacy.•Sulfate content, molecular mass and glycosyl composition affect the antiviral potency. Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide −SO3/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2015.06.019