Pyrimidine Metabolism： Dynamic and Versatile Pathways in Pathogens and Cellular Development

The importance of pyrimidines lies in the fact that they are structural components of a broad spectrum of key molecules that participate in diverse cellular functions, such as synthesis of DNA, RNA, lipids, and carbohydrates. Pyrimidine metabolism encompasses all enzymes involved in the synthesis, d...

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Bibliographic Details
Published in:Journal of genetics and genomics 2015-05, Vol.42 (5), p.195-205
Main Authors: Garavito, Manuel F., Narváez-Ortiz, Heidy Y., Zimmermann, Barbara H.
Format: Article
Language:English
Subjects:
Animals
CAD
Cells - cytology
Cells - metabolism
Cells - pathology
Computational Biology
Dihydroorotase
Dihydroorotate dehydrogenase
Humans
Infection - metabolism
Infection - pathology
Pathogens
Pyrimidine metabolism
Pyrimidines - metabolism
UMP synthase
代谢组学
病原体感染
碳水化合物
细胞功能
细胞发育
结构部件
胞嘧啶
蛋白质组学
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Summary:The importance of pyrimidines lies in the fact that they are structural components of a broad spectrum of key molecules that participate in diverse cellular functions, such as synthesis of DNA, RNA, lipids, and carbohydrates. Pyrimidine metabolism encompasses all enzymes involved in the synthesis, degradation, salvage, interconversion and transport of these molecules. In this review, we summarize recent publications that document how pyrimidine metabolism changes under a variety of conditions, including, when possible, those studies based on techniques of genomics, transcriptomics, proteomics, and metabolomics. First, we briefly look at the dynamics of pyrimidine metabolism during nonpathogenic cellular events. We then focus on changes that pathogen infections cause in the pyrimidine metabolism of their host. Next, we discuss the effects of antimetabolites and inhibitors, and finally we consider the consequences of genetic ma- nipulations, such as knock-downs, knock-outs, and knock-ins, of pyrimidine enzymes on pyrimidine metabolism in the cell.
ISSN:1673-8527
DOI:10.1016/j.jgg.2015.04.004