An electrophysiological evaluation of serotonergic dorsal raphe neurons in maudsley rats

Extracellular electrophysiological recording techniques were used to study serotonergic dorsal raphe (DRN) neurons in Maudsley Reactive (MR), Maudsley Non-Reactive (MNRA) and Sprague Dawley (SD; reference control strain) rats. No significant differences were observed in the average discharge rates o...

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Bibliographic Details
Published in:Life sciences (1973) 1995-12, Vol.58 (3), p.245-250
Main Authors: Verbanac, John S., Commissaris, Randall L., Pitts, David K.
Format: Article
Language:English
Subjects:
electrophysiological evaluation
Maudsley rats
serotonergic dorsal raphe neurons
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Summary:Extracellular electrophysiological recording techniques were used to study serotonergic dorsal raphe (DRN) neurons in Maudsley Reactive (MR), Maudsley Non-Reactive (MNRA) and Sprague Dawley (SD; reference control strain) rats. No significant differences were observed in the average discharge rates of DRN neurons from SD, MR and MNRA rats. The sensitivity of DRN neuron somatodendritic 5-HT1 A autoreceptors to the inhibitory effects of i.v. 8-OH-DPAT or α 1-adrenoceptors to the excitatory effects of iontophoretic phenylephrine did not differ significantly among strains. These findings are discussed in light of the previously reported strain-dependent differences in anxiety-like behavior and noradrenergic locus coeruleus neurons.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(95)02282-1