Loading…
Xenopus Brachyury
Study of Xenopus Brachyury, Xbra, has concentrated on its activation by mesoderm induction and on the effects of over-expression of the gene. Activation of Xbra is an immediate-early response to the mesoderm-inducing factors FGF and activin. The effects of FGF can be mimicked by constitutively activ...
Saved in:
Published in: | Seminars in developmental biology 1995, Vol.6 (6), p.405-410 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Study of
Xenopus Brachyury, Xbra, has concentrated on its activation by mesoderm induction and on the effects of over-expression of the gene. Activation of
Xbra is an immediate-early response to the mesoderm-inducing factors FGF and activin. The effects of FGF can be mimicked by constitutively active components of the MAP kinase cascade. Over-expression of
Xbra in presumptive ectodermal tissue causes ectopic mesoderm formation, with different types of mesoderm being formed in response to different concentrations of Xbra. Future work will study the
Brachyury promoter and will attempt to identify targets of this presumptive transcription factor. |
---|---|
ISSN: | 1044-5781 1878-7347 |
DOI: | 10.1016/S1044-5781(06)80004-6 |