Degradation systems in heart failure

Abstract Heart failure is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or the ejection of blood, and is a leading cause of morbidity and mortality in industrialized countries. The mechanisms underlying the development of heart failure a...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2015-07, Vol.84, p.212-222
Main Authors: Nishida, Kazuhiko, Yamaguchi, Osamu, Otsu, Kinya
Format: Article
Language:English
Subjects:
Animals
Autophagy
Calpain
Cardiovascular
Heart failure
Heart Failure - metabolism
Humans
Inflammation
Models, Biological
Myocardium - metabolism
Myocardium - pathology
Nucleic Acids - metabolism
Proteolysis
Ubiquitin proteasome system
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Summary:Abstract Heart failure is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or the ejection of blood, and is a leading cause of morbidity and mortality in industrialized countries. The mechanisms underlying the development of heart failure are multiple, complex and not well understood. Cardiac mass and its homeostasis are maintained by the balance between protein synthesis and degradation, and an imbalance is likely to result in cellular dysfunction and disease. The protein degradation systems are the principle mechanisms for maintaining cellular homeostasis via protein quality control. Three major protein degradation systems have been identified, namely the calpain system, autophagy, and the ubiquitin proteasome system. Proinflammatory mediators involve the development and progression of heart failure. DNA and RNA degradation systems play a critical role in regulating inflammation and maintaining cellular homeostasis mediated by damaged DNA clearance and posttranscriptional regulation, respectively. This review discusses some recent advances in understanding the role of these degradation systems in heart failure.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2015.05.004