Cellularity, characteristics of hematopoietic parameters and prognosis in myelodysplastic syndromes

Background Myelodysplastic syndromes (MDS) present with a normo‐ or hyperplastic bone marrow in most cases. We aimed at a characterization of patients with different types of cellularity. Methods We assessed marrow cellularity both by histology and cytology in 1270 patients and analyzed hematologic,...

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Published in:European journal of haematology 2015-09, Vol.95 (3), p.181-189
Main Authors: Schemenau, Jennifer, Baldus, Stephan, Anlauf, Martin, Reinecke, Petra, Braunstein, Stefan, Blum, Sabine, Nachtkamp, Kathrin, Neukirchen, Judith, Strup, Corinna, Aul, Carlo, Haas, Rainer, Gattermann, Norbert, Germing, Ulrich
Format: Article
Language:English
Subjects:
Bone Marrow - pathology
bone marrow cellularity
cytogenetics
Disease Progression
Female
Hematologic Tests
Humans
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - etiology
Male
myelodysplastic syndromes
Myelodysplastic Syndromes - blood
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - mortality
Myelodysplastic Syndromes - pathology
Prognosis
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Summary:Background Myelodysplastic syndromes (MDS) present with a normo‐ or hyperplastic bone marrow in most cases. We aimed at a characterization of patients with different types of cellularity. Methods We assessed marrow cellularity both by histology and cytology in 1270 patients and analyzed hematologic, cytogenetic, and prognostic parameters accordingly. Results The concordance of the assessment of cellularity differed dramatically between histology and cytology as only 36.5% were described as hypocellular by both methods (P 
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.12512