Comprehensive Analysis of Functional Outcomes and Survival After Microvascular Reconstruction of Glossectomy Defects

Background Few studies on tongue reconstruction provide a comprehensive, multidisciplinary analysis examining defect size, flap selection, function, and long-term survival. This report presents the largest study in the literature evaluating free flap reconstruction after glossectomy. Methods A retro...

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Bibliographic Details
Published in:Annals of surgical oncology 2015-09, Vol.22 (9), p.3061-3069
Main Authors: Chang, Edward I., Yu, Peirong, Skoracki, Roman J., Liu, Jun, Hanasono, Matthew M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Deglutition
Female
Follow-Up Studies
Free Tissue Flaps - blood supply
Glossectomy - mortality
Humans
Male
Medicine
Medicine & Public Health
Microvessels - surgery
Middle Aged
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Neoplasm Staging
Oncology
Postoperative Complications
Prognosis
Reconstructive Oncology
Reconstructive Surgical Procedures - mortality
Retrospective Studies
Surgery
Surgical Oncology
Survival Rate
Tongue Neoplasms - mortality
Tongue Neoplasms - pathology
Tongue Neoplasms - surgery
Vascular Surgical Procedures - mortality
Young Adult
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Summary:Background Few studies on tongue reconstruction provide a comprehensive, multidisciplinary analysis examining defect size, flap selection, function, and long-term survival. This report presents the largest study in the literature evaluating free flap reconstruction after glossectomy. Methods A retrospective review of patients undergoing free flap glossectomy reconstruction from 2000 to 2012 was performed. Results In this review, 268 patients were identified. Resections involving the tongue only included 59 partial glossectomies, 86 hemiglossectomies, 28 subtotal glossectomies, and 24 total glossectomies. Glossectomies performed with mandibulectomies were analyzed independently for speech and swallowing function (32 partial glossectomies, 18 hemiglossectomies, 8 subtotal glossectomies, and 13 total glossectomies with mandibulectomy). A total of 299 free flaps were performed, with 30 patients receiving two free flaps. Multivariate analysis demonstrating smoking ( p  = 0.018), composite resections ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-015-4386-6