Modifying Effects of Nanosized Diamonds on Hydrolytic Potential of Macrophages In Vitro

The effects of nanosized particles (4–6 nm) of synthetic diamonds on mouse macrophage expression and secretion of lysosomal cathepsins (B and D) and MMP-1 and MMP-9 were studied in vitro . Culturing of peritoneal macrophages in medium with diamond nanoparticles led to an increase in the counts of ma...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-07, Vol.159 (3), p.398-401
Main Authors: Neshchadim, D. V., Arkhipov, S. A., Shkurupy, V. A., Akhramenko, E. S., Troitskii, A. V., Karpov, M. A.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Biotechnologies
Cathepsins
Cathepsins - metabolism
Cell Biology
Diamond - chemistry
Diamonds
Enzymes
Hydrolysis
Internal Medicine
Laboratory Medicine
Macrophages
Macrophages - drug effects
Macrophages - metabolism
Male
Metalloproteases - metabolism
Mice
Mice, Inbred BALB C
Nanoparticles - chemistry
Pathology
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Summary:The effects of nanosized particles (4–6 nm) of synthetic diamonds on mouse macrophage expression and secretion of lysosomal cathepsins (B and D) and MMP-1 and MMP-9 were studied in vitro . Culturing of peritoneal macrophages in medium with diamond nanoparticles led to an increase in the counts of macrophages expressing the above enzymes and to stimulation of their secretion. However, the manifestations of these effects varied significantly for various enzymes. The data indicate modulation of macrophage functions by nanodiamonds. These results help better understand the possible role of the “corpuscular” xenobiotic factors in the pathogenesis of diseases associated with macrophage capturing of these factors irrespective of their chemical “activity”.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2973-y