The effects of intracerebroventricular infusion of apelin-13 on reproductive function in male rats

•Infusion of central apelin-13 can suppress LH pulse.•Apelin-13 decreases serum testosterone levels.•Apelin-13 may cause infertility in male rats. Apelin is a novel bioactive peptide as the endogenous ligand for APJ. Apelin and APJ have also been identified in the testis, hypothalamic nuclei such as...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2015-08, Vol.602, p.133-138
Main Authors: Sandal, Suleyman, Tekin, Suat, Seker, Fatma Burcu, Beytur, Ali, Vardi, Nigar, Colak, Cemil, Tapan, Tuba, Yildiz, Sedat, Yilmaz, Bayram
Format: Article
Language:English
Subjects:
Animals
Apelin
Apelin Receptors
Follicle Stimulating Hormone - blood
FSH
Infusions, Intraventricular
Intercellular Signaling Peptides and Proteins - metabolism
Intercellular Signaling Peptides and Proteins - pharmacology
Leydig cell
Leydig Cells - cytology
Leydig Cells - drug effects
Ligands
Luteinizing Hormone - blood
Male
Rats, Wistar
Receptors, G-Protein-Coupled - metabolism
Reproduction function
Seminiferous Tubules - cytology
Seminiferous Tubules - drug effects
Testis - cytology
Testis - drug effects
Testosterone
Testosterone - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Infusion of central apelin-13 can suppress LH pulse.•Apelin-13 decreases serum testosterone levels.•Apelin-13 may cause infertility in male rats. Apelin is a novel bioactive peptide as the endogenous ligand for APJ. Apelin and APJ have also been identified in the testis, hypothalamic nuclei such as arcuate, supraoptic and paraventricular nuclei, implicating roles in the control of reproduction. Therefore, the present study was designed to investigate the effects of chronic central infusion of apelin-13 on LH, FSH and testosterone levels and testis morphology. 21 Wistar–Albino male rats received continuous intracerebroventricular infusion via Alzet osmotic mini pumps filled artificial cerebrospinal fluid (vehicle) or apelin-13 at concentrations of 1 or 10nmol (10μl/h) for seven days. At the last 90min of the infusion period, the blood samples were collected at 15min intervals (0–90min) for LH and FSH analyses. At the last sampling point, the blood samples were analyzed for testosterone levels. Infusion of high dose apelin-13 significantly suppressed LH release compared with the vehicle values at 30, 60 and 75min (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2015.06.059