Resistant hypertension: do all definitions describe the same patients?

Resistant hypertension (RH) is defined as blood pressure (BP) that remains ⩾140 and/or 90 mm Hg despite therapy with ⩾3 full-dose antihypertensive drugs (classical definition=CD). A definition proposed subsequently (new definition=ND) includes patients requiring ⩾4 drugs irrespective of BP values. W...

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Bibliographic Details
Published in:Journal of human hypertension 2015-09, Vol.29 (9), p.530-534
Main Authors: Boswell, L, Pascual, J, Oliveras, A
Format: Article
Language:English
Subjects:
692/499
Aged
Analysis
Antihypertensive agents
Antihypertensive Agents - therapeutic use
Antihypertensives
Biomarkers - blood
Blood Glucose - metabolism
Blood pressure
Blood Pressure - drug effects
Care and treatment
Chi-Square Distribution
Cholesterol
Comorbidity
Diabetes
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - epidemiology
Drug Resistance
Drug Therapy, Combination
Dyslipidemias - blood
Dyslipidemias - epidemiology
Epidemiology
Female
Genetic aspects
Health Administration
Health aspects
Humans
Hypertension
Hypertension - blood
Hypertension - classification
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - physiopathology
LDL cholesterol
Lipids - blood
Logistic Models
Low density lipoprotein
Male
Measurement
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Odds Ratio
original-article
Phenotype
Physiological aspects
Prevalence
Public Health
Retrospective Studies
Risk Factors
Terminology as Topic
Treatment Failure
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Description
Summary:Resistant hypertension (RH) is defined as blood pressure (BP) that remains ⩾140 and/or 90 mm Hg despite therapy with ⩾3 full-dose antihypertensive drugs (classical definition=CD). A definition proposed subsequently (new definition=ND) includes patients requiring ⩾4 drugs irrespective of BP values. We aimed to evaluate whether both definitions characterize the same kind of patients.One hundred and twenty-four consecutively attended patients with RH were classified into two groups according to their BP control: 66 patients had non-controlled BP (all those who met the CD criteria plus a few patients who met the ND criteria); 58 patients had controlled BP (all with RH according to the ND). Clinical, laboratory and office BP data were recorded. RH patients with non-controlled BP were more frequently diabetic (72% vs 49%), and had higher plasmatic glucose (149 vs 130 mg dl −1 ), cholesterol (179 vs 164 mg dl −1 ), low-density lipoprotein (LDL)-cholesterol (107 vs 95 mg dl −1 ) and triglyceride (169 vs 137 mg dl −1 ) levels; P
ISSN:0950-9240
1476-5527
DOI:10.1038/jhh.2014.128