Tendon grafts: their natural history, biology and future development

The use of tendon grafts has diminished as regimes of primary repairs and rehabilitation have improved, but they remain important in secondary reconstruction. Relatively little is known about the cellular biology of grafts, and the general perception is that they have little biological activity. The...

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Bibliographic Details
Published in:Journal of Hand Surgery (European Volume) 2015-09, Vol.40 (7), p.669-681
Main Authors: Wong, R., Alam, N., McGrouther, A. D., Wong, J. K. F.
Format: Article
Language:English
Subjects:
Cell Movement
Coated Materials, Biocompatible
Collagen - physiology
Fibroblasts - cytology
Finger Injuries - surgery
Forecasting
Gene Expression
History, 19th Century
History, 20th Century
Humans
Microsurgery - trends
Orthopedic Fixation Devices
Orthopedic Procedures - history
Orthopedic Procedures - trends
Regeneration
Suture Techniques
Tendon Injuries - surgery
Tendons - blood supply
Tendons - transplantation
Tissue Adhesions - prevention & control
Tissue Engineering - trends
Wound Healing - physiology
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Summary:The use of tendon grafts has diminished as regimes of primary repairs and rehabilitation have improved, but they remain important in secondary reconstruction. Relatively little is known about the cellular biology of grafts, and the general perception is that they have little biological activity. The reality is that there is a wealth of cellular and molecular changes occurring with the process of engraftment that affect the quality of the repair. This review highlights the historical perspectives and modern concepts of graft take, reviews the different attachment techniques and revisits the biology of pseudosheath formation. In addition, we discuss some of the future directions in tendon reconstruction by grafting, which include surface modification, vascularized tendon transfer, allografts, biomaterials and cell-based therapies.
ISSN:1753-1934
2043-6289
DOI:10.1177/1753193415595176