Supramolecular interaction of a cancer cell photosensitizer in the nanocavity of cucurbit[7]uril: A spectroscopic and calorimetric study

[Display omitted] •Interaction of a cancer cell photosensitizer molecule harmane with CB7 was reported.•Emission properties of harmane was modulated several folds in the presence of CB7.•Thermodynamics of the binding was studied by using isothermal titration calorimetry.•Stoichiometry of the complex...

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Bibliographic Details
Published in:International journal of pharmaceutics 2015-08, Vol.492 (1-2), p.103-108
Main Authors: Ahmed, Sayeed Ashique, Chatterjee, Aninda, Maity, Banibrata, Seth, Debabrata
Format: Article
Language:English
Subjects:
Bridged-Ring Compounds - chemistry
Calorimetry
Cancer cell photosensitizer
Cucurbituril
Drug encapsulation
Fluorescence
Harmine - analogs & derivatives
Harmine - chemistry
Imidazoles - chemistry
Isothermal titration calorimetry
Nanostructures - chemistry
Neoplasms - drug therapy
Photosensitizing Agents - chemistry
Spectrometry, Fluorescence
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Summary:[Display omitted] •Interaction of a cancer cell photosensitizer molecule harmane with CB7 was reported.•Emission properties of harmane was modulated several folds in the presence of CB7.•Thermodynamics of the binding was studied by using isothermal titration calorimetry.•Stoichiometry of the complex was found to be 1:1 in the excited state. The interaction of small biologically active molecules in the nanocavity of supramolecular host is very interesting and thriving research area. In the presence of supramolecular host the absorption and emission properties of small biologically active molecules were modulated several folds compared to bulk solution. In this study we have investigated the supramolecular interaction of a cancer cell photosensitizer molecule harmane in the presence of cucurbit[7]uril (CB7) as host in aqueous buffer solution (pH∼7.2). We have used steady state absorption, emission and time resolved fluorescence spectroscopy techniques. The thermodynamics of the binding between harmane in the nanochannel of CB7 were studied by using isothermal titration calorimetry (ITC) method. The emission properties of harmane are modulated several fold in the presence of CB7. ITC study indicates that the complexation between harmane and CB7 are enthalpically favourable.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2015.07.016