Folates and aging: Role in mild cognitive impairment, dementia and depression

Highlights • Folate deficiency is prevalent in older individuals due to intestinal malabsorption. • Onset and progression of cognitive disorders is associated with a low folate status. • Hyperhomocysteinemia is the most important mechanism underlying this association. • It is unclear if folate suppl...

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Bibliographic Details
Published in:Ageing research reviews 2015-07, Vol.22, p.9-19
Main Authors: Araújo, João Ricardo, Martel, Fátima, Borges, Nuno, Araújo, João Manuel, Keating, Elisa
Format: Article
Language:English
Subjects:
Aged
Aging - physiology
Aging - psychology
Brain - metabolism
Cognition - drug effects
Cognitive Dysfunction - etiology
Cognitive Dysfunction - metabolism
Cognitive Dysfunction - prevention & control
Dementia - etiology
Dementia - metabolism
Dementia - prevention & control
Depression - etiology
Depression - metabolism
Disease Progression
Folic Acid - metabolism
Folic Acid - pharmacology
Folic Acid Deficiency - complications
Folic Acid Deficiency - metabolism
Humans
Internal Medicine
Intestinal Absorption
Neurology
Vitamin B Complex - metabolism
Vitamin B Complex - pharmacology
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Summary:Highlights • Folate deficiency is prevalent in older individuals due to intestinal malabsorption. • Onset and progression of cognitive disorders is associated with a low folate status. • Hyperhomocysteinemia is the most important mechanism underlying this association. • It is unclear if folate supplementation improves cognition in older individuals.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2015.04.005