Silica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptor

Highlights • Overview of the current understanding and recent data on the role of ATP and P2X7 receptor in silica-induced inflammasome activation. • Inflammasome assembly in macrophages during silicosis: mechanisms of how silica particles are sensed by the NALP3 inflammasome. • Role of ATP in NLRP3...

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Bibliographic Details
Published in:Immunobiology (1979) 2015-09, Vol.220 (9), p.1101-1106
Main Authors: Luna-Gomes, Tatiana, Santana, Patricia Teixeira, Coutinho-Silva, Robson
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Advanced Basic Science
Allergy and Immunology
ATP
Carrier Proteins - immunology
Carrier Proteins - metabolism
Enzyme Activation - immunology
Humans
Inflammasome
Inflammasomes - immunology
Interleukin 1β
Lung Injury - immunology
Lung Injury - pathology
Macrophage Activation - immunology
Macrophages - immunology
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3
P2X7 receptor
Receptors, Purinergic P2X7 - immunology
Signal Transduction - immunology
Silica
Silicon Dioxide - immunology
Silicosis - immunology
Silicosis - pathology
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Summary:Highlights • Overview of the current understanding and recent data on the role of ATP and P2X7 receptor in silica-induced inflammasome activation. • Inflammasome assembly in macrophages during silicosis: mechanisms of how silica particles are sensed by the NALP3 inflammasome. • Role of ATP in NLRP3 activation via P2X7 receptors. • Involvement of the P2X7 receptors in silica-induced NLRP3 activation.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2015.05.004