Alteration of the reaction rate in the esterification of (R,S) ibuprofen by addition of crown ether or porphyrin

The reaction yield of the esterification of (R,S) ibuprofen with n-propanol, catalyzed by physically adsorbed Candida antarctica lipase B on anionic resin, is improved by the addition of benzo-[18]-crown-6 or meso-tetraphenylporphyrin but reduced by the presence of metal-porphyrins. The interaction...

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Bibliographic Details
Published in:Biotechnology letters 1996, Vol.18 (1), p.85-90
Main Authors: GRADILLAS, A, DEL CAMPO, C, SINISTERRA, J. V, LLAMA, E. F
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Candida antarctica
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
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Summary:The reaction yield of the esterification of (R,S) ibuprofen with n-propanol, catalyzed by physically adsorbed Candida antarctica lipase B on anionic resin, is improved by the addition of benzo-[18]-crown-6 or meso-tetraphenylporphyrin but reduced by the presence of metal-porphyrins. The interaction of benzo-[18]-crown-6 or meso-tetraphenyl porphyrin with the lid of pure lipase B on C. antarctica, would produce the activation of the lipase increasing the reaction rate but not the enantioselectivity.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF00137816