The Thyroid Hormone-Induced Tail Resorption Program during Xenopus laevis Metamorphosis

Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 dow...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1996-03, Vol.93 (5), p.1924-1929
Main Authors: Brown, Donald D., Wang, Zhou, Furlow, J. David, Kanamori, Akira, Schwartzman, Robert A., Remo, Benjamin F., Pinder, Allison
Format: Article
Language:English
Subjects:
Amino acids
Animals
Base Sequence
Complementary DNA
Embryos
Endopeptidases - metabolism
Enzymes
Freshwater
Gene Expression Regulation, Developmental
Genes
Genetics
Hormones
Messenger RNA
Metamorphosis
Metamorphosis, Biological
Molecular Sequence Data
Neoplasm Metastasis
Open reading frames
Proteins
RNA, Messenger - genetics
Tadpoles
Thyroid Hormones - physiology
Tissue Distribution
Transcription Factors - physiology
Xenopus laevis
Xenopus laevis - growth & development
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Summary:Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; 17 and 4 of them, respectively, have been isolated and characterized. Up-regulated genes whose function can be predicted on the basis of their sequence include four transcription factors (including one of the thyroid hormone receptors), an extracellular matrix component (fibronectin) and membrane receptor (integrin), four proteinases, a deiodinase that degrades thyroid hormone, and a protein that binds the hypothalamic corticotropin-releasing factor, which has been implicated in controlling thyroid hormone synthesis in Xenopus tadpoles. All four down-regulated genes encode extracellular proteins that are expressed in tadpole epidermis. This survey of the program provides insights into the biology of metamorphosis.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.93.5.1924