Postinjection suppression of drinking is modified by the presence of conditioned contextual cues: implications for both anticipatory and posttreatment nausea in humans

In three experiments, we set out to determine whether the response of rats to an injection of LiCl would be modified by the presence of an environmental context that had previously been paired with LiCl. Experiment 1 confirmed that one feature of the malaise produced by LiCl is a reduced tendency to...

Full description

Saved in:
Bibliographic Details
Published in:Animal learning & behavior 2002-11, Vol.30 (4), p.355-362
Main Authors: Symonds, Michelle, Hall, Geoffrey
Format: Article
Language:English
Subjects:
Animals
Association Learning
Avoidance Learning
Conditioning, Classical
Drinking
Lithium Chloride - toxicity
Male
Rats
Rats, Inbred Strains
Retention (Psychology)
Social Environment
Taste
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In three experiments, we set out to determine whether the response of rats to an injection of LiCl would be modified by the presence of an environmental context that had previously been paired with LiCl. Experiment 1 confirmed that one feature of the malaise produced by LiCl is a reduced tendency to consume an otherwise palatable flavor. Experiment 2 showed that the size of this response was enhanced if it was measured in the presence of a conditioned context. In Experiment 3, we investigated the possibility that the postinjection response could be modified by an overshadowing treatment given during the conditioning phase. The significance of these findings for the understanding of chemotherapy-induced nausea in the clinical population is discussed.
ISSN:0090-4996
1532-5830
DOI:10.3758/BF03195960