Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice

Highlights • CR can decrease body weight and serum glucose. • CR activates SIRT1 and suppresses the mTOR pathway in brain. • We showed the relationship between CR and the SIRT1/mTOR pathways.

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Bibliographic Details
Published in:Brain research bulletin 2015-07, Vol.116, p.67-72
Main Authors: Ma, Lina, Dong, Wen, Wang, Rong, Li, Yun, Xu, Baolei, Zhang, Jingshuang, Zhao, Zhiwei, Wang, Yulan
Format: Article
Language:English
Subjects:
Animals
Blood Glucose
Blotting, Western
Body Weight
Caloric Restriction
Dementia - diet therapy
Dementia - metabolism
Dementia - pathology
Fluorescent Antibody Technique
Hippocampus - metabolism
Hippocampus - pathology
Male
Mice, Inbred C57BL
mTOR
Neurology
Neurons - metabolism
Neurons - pathology
Real-Time Polymerase Chain Reaction
Ribosomal Protein S6 Kinases, 90-kDa - metabolism
RNA, Messenger - metabolism
S6K1
Signal Transduction
SIRT1
Sirtuin 1 - metabolism
TOR Serine-Threonine Kinases - metabolism
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Description
Summary:Highlights • CR can decrease body weight and serum glucose. • CR activates SIRT1 and suppresses the mTOR pathway in brain. • We showed the relationship between CR and the SIRT1/mTOR pathways.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2015.06.004