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Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish
Apolipoprotein C1 （Apocl） is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoclb, a transcript isoform of Apocl, in epiboly during zebrafish gastrulation. Apoclb is expressed in yolk syncytial layers and in de...
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| Published in: | Science China. Life sciences 2013-11, Vol.56 (11), p.975-984 |
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| creator | Wang, Yang Zhou, Li Li, Zhi Li, WenHua Gui, JianFang |
| description | Apolipoprotein C1 （Apocl） is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoclb, a transcript isoform of Apocl, in epiboly during zebrafish gastrulation. Apoclb is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a ra- dial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoclb by injecting antisense morpholino （MO） caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the ra- dial gradient distribution of E-cadherin are disrupted both in Apoclb knockdown and overexpressed embryos. Therefore, Apoc 1 b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner. |
| doi_str_mv | 10.1007/s11427-013-4563-4 |
| format | article |
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We reveal a new function of Apoclb, a transcript isoform of Apocl, in epiboly during zebrafish gastrulation. Apoclb is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a ra- dial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoclb by injecting antisense morpholino （MO） caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the ra- dial gradient distribution of E-cadherin are disrupted both in Apoclb knockdown and overexpressed embryos. Therefore, Apoc 1 b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><identifier>DOI: 10.1007/s11427-013-4563-4</identifier><identifier>PMID: 24203452</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Amino Acid Sequence ; Animals ; Apolipoprotein C-I - chemistry ; Apolipoprotein C-I - genetics ; Apolipoprotein C-I - metabolism ; Base Sequence ; Biomedical and Life Sciences ; Cadherins - metabolism ; Cell Movement - genetics ; Cover Article ; Danio rerio ; Gastrulation - genetics ; Gastrulation - physiology ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Life Sciences ; Protein Isoforms ; Zebrafish - embryology ; Zebrafish - genetics ; Zebrafish - metabolism ; Zebrafish Proteins - chemistry ; Zebrafish Proteins - genetics ; Zebrafish Proteins - metabolism ; 原肠胚 ; 外包 ; 斑马鱼 ; 梯度分布 ; 胚胎发育过程 ; 蛋白代谢 ; 调控 ; 载脂蛋白C</subject><ispartof>Science China. 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Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>Apolipoprotein C1 （Apocl） is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoclb, a transcript isoform of Apocl, in epiboly during zebrafish gastrulation. Apoclb is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a ra- dial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoclb by injecting antisense morpholino （MO） caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the ra- dial gradient distribution of E-cadherin are disrupted both in Apoclb knockdown and overexpressed embryos. Therefore, Apoc 1 b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Apolipoprotein C-I - chemistry</subject><subject>Apolipoprotein C-I - genetics</subject><subject>Apolipoprotein C-I - metabolism</subject><subject>Base Sequence</subject><subject>Biomedical and Life Sciences</subject><subject>Cadherins - metabolism</subject><subject>Cell Movement - genetics</subject><subject>Cover Article</subject><subject>Danio rerio</subject><subject>Gastrulation - genetics</subject><subject>Gastrulation - physiology</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Knockdown Techniques</subject><subject>Life Sciences</subject><subject>Protein Isoforms</subject><subject>Zebrafish - embryology</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - metabolism</subject><subject>Zebrafish Proteins - chemistry</subject><subject>Zebrafish Proteins - genetics</subject><subject>Zebrafish Proteins - metabolism</subject><subject>原肠胚</subject><subject>外包</subject><subject>斑马鱼</subject><subject>梯度分布</subject><subject>胚胎发育过程</subject><subject>蛋白代谢</subject><subject>调控</subject><subject>载脂蛋白C</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkcFO3DAQhq0KVBDwAL1UQVy4BMb2xJMc0Za2SEhc2rPlZCdLUDYOdnKAp6_T3aKqB-qDbXm--Wc8vxCfJFxJALqOUqKiHKTOsTBp-yCOZWmqXJZldZDuhjAnDcWROIvxCdLSGhTRR3GkUIHGQh2LLzej77vRj8FP3A3ZSmaBN3PvJo4Zj13t-5dsPYdu2GQbF6ewhDo_ZIl95Tq4touPp-KwdX3ks_15In5-vf2x-p7fP3y7W93c5w0STnlbqtrJ2gDDuipVxQU2DbdICtp1TRUZSq-mciyplnWiUtwxOirQlRr1ibjc6aZun2eOk912seG-dwP7OVpJUEAlgej_KGKqpw3KhF78gz75OQzpI78pVVRGqUTJHdUEH2Pg1o6h27rwYiXYxRC7M8QmQ-xiiF36_bxXnustr98y_ow_AWoHxHGZMIe_Sr-jer7v5NEPm-eU9yaMZECBQf0LcQ-fdw</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Wang, Yang</creator><creator>Zhou, Li</creator><creator>Li, Zhi</creator><creator>Li, WenHua</creator><creator>Gui, JianFang</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20131101</creationdate><title>Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish</title><author>Wang, Yang ; Zhou, Li ; Li, Zhi ; Li, WenHua ; Gui, JianFang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-f82ba1b60e0d9829e54ccef4720fdb7976782969ae17b1be0d4ccae4a754a8343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Apolipoprotein C-I - chemistry</topic><topic>Apolipoprotein C-I - genetics</topic><topic>Apolipoprotein C-I - metabolism</topic><topic>Base Sequence</topic><topic>Biomedical and Life Sciences</topic><topic>Cadherins - metabolism</topic><topic>Cell Movement - genetics</topic><topic>Cover Article</topic><topic>Danio rerio</topic><topic>Gastrulation - genetics</topic><topic>Gastrulation - physiology</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Knockdown Techniques</topic><topic>Life Sciences</topic><topic>Protein Isoforms</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish - metabolism</topic><topic>Zebrafish Proteins - chemistry</topic><topic>Zebrafish Proteins - genetics</topic><topic>Zebrafish Proteins - metabolism</topic><topic>原肠胚</topic><topic>外包</topic><topic>斑马鱼</topic><topic>梯度分布</topic><topic>胚胎发育过程</topic><topic>蛋白代谢</topic><topic>调控</topic><topic>载脂蛋白C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Li, Zhi</creatorcontrib><creatorcontrib>Li, WenHua</creatorcontrib><creatorcontrib>Gui, JianFang</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Science China. Life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yang</au><au>Zhou, Li</au><au>Li, Zhi</au><au>Li, WenHua</au><au>Gui, JianFang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish</atitle><jtitle>Science China. Life sciences</jtitle><stitle>Sci. China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>56</volume><issue>11</issue><spage>975</spage><epage>984</epage><pages>975-984</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>Apolipoprotein C1 （Apocl） is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoclb, a transcript isoform of Apocl, in epiboly during zebrafish gastrulation. Apoclb is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a ra- dial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoclb by injecting antisense morpholino （MO） caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the ra- dial gradient distribution of E-cadherin are disrupted both in Apoclb knockdown and overexpressed embryos. Therefore, Apoc 1 b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>24203452</pmid><doi>10.1007/s11427-013-4563-4</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Apolipoprotein C-I - chemistry Apolipoprotein C-I - genetics Apolipoprotein C-I - metabolism Base Sequence Biomedical and Life Sciences Cadherins - metabolism Cell Movement - genetics Cover Article Danio rerio Gastrulation - genetics Gastrulation - physiology Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockdown Techniques Life Sciences Protein Isoforms Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - chemistry Zebrafish Proteins - genetics Zebrafish Proteins - metabolism 原肠胚 外包 斑马鱼 梯度分布 胚胎发育过程 蛋白代谢 调控 载脂蛋白C |
| title | Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish |
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