Visual evoked potentials in individuals exposed to long-term low concentrations of toluene

An investigation of visual evoked potentials was carried out in two groups of subjects; 49 workers employed in a printing-prss where toluene has been used exclusively as an organic solvent for the last 30 years, and 59 workers not occupationally exposed to any known neurotoxic substances. The averag...

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Bibliographic Details
Published in:Archives of toxicology 1995, Vol.69 (5), p.337-340
Main Authors: VRCA, A, BOZICEVIC, D, KARACIC, V, FUCHS, R, PRPIC-MAJIC, D, MALINAR, M
Format: Article
Language:English
Subjects:
Alcohol Drinking
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Evoked Potentials, Visual - drug effects
Humans
Medical sciences
Occupational Exposure - adverse effects
Solvents
Time Factors
Toluene - poisoning
Toxicology
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Summary:An investigation of visual evoked potentials was carried out in two groups of subjects; 49 workers employed in a printing-prss where toluene has been used exclusively as an organic solvent for the last 30 years, and 59 workers not occupationally exposed to any known neurotoxic substances. The average length of work service in the printing-press was 21.4 years. The level of exposure was assessed by determination of the concentration of toluene in peripheral blood, the concentration of hippuric acid and ortho-cresol in urine in subgroups of subjects chosen at random from both groups. N75, P100 and N145 waves of the pattern reversal visual evoked potentials were analyzed. In the group of exposed subjects, significantly greater amplitudes were found in all waves, with significantly longer latency of the P100 wave.
ISSN:0340-5761
1432-0738
DOI:10.1007/s002040050180