Cryptosporidium parvum: Intensity of Infection and Oocyst Excretion Patterns in Healthy Volunteers

Data about human Cryptosporidium parvum infection have originated from travelers, community and day care center outbreaks, and persons infected with the human immunodeficiency virus. In addition, experimental infection in 29 antibody-negative, healthy, adult volunteers generated information on the d...

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Bibliographic Details
Published in:The Journal of infectious diseases 1996-01, Vol.173 (1), p.232-236
Main Authors: Chappell, Cynthia L., Okhuysen, Pablo C., Sterling, Charles R., DuPont, Herbert L.
Format: Article
Language:English
Subjects:
AIDS
Animals
Biological and medical sciences
Cryptosporidiosis
Cryptosporidiosis - parasitology
Cryptosporidiosis - transmission
Cryptosporidium parvum
Cryptosporidium parvum - isolation & purification
Cryptosporidium parvum - pathogenicity
Diarrhea
Diarrhea - parasitology
Disease Susceptibility
Diseases
Dosage
Excretion
Feces - parasitology
Human protozoal diseases
Humans
Infections
Infectious diseases
Medical sciences
Oocysts
Parasite Egg Count
Parasitic diseases
Protozoal diseases
Symptoms
Travel
Volunteerism
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Summary:Data about human Cryptosporidium parvum infection have originated from travelers, community and day care center outbreaks, and persons infected with the human immunodeficiency virus. In addition, experimental infection in 29 antibody-negative, healthy, adult volunteers generated information on the dose-infection response of C. parvum (Iowa strain). In that report, low inocula were sufficient to cause infection in 18 and illness in 7 persons. To further define the duration and intensity of infectionin this population, oocyst shedding patterns were investigated in the 18 subjects infected with C. parvum. Oocyst quantitation revealed that volunteers with diarrheal illness (n = 7) excreted more oocysts over the course of the infection than did volunteers without diarrhea (n = 11; P < .05). Symptomatic subjects were more likely to shed oocystson consecutive days. Further, a statistical nonsignificant inverse trend (r2 = .330, P = .136) was seen between challenge dose and total excreted oocysts. This paradox may relate to receptor saturation or a toxic effect on cells, parasites, or both afforded by a high inoculum.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/173.1.232