Combined volumetric T sub(1), T sub(2) and secular-T sub(2) quantitative MRI of the brain: age-related global changes (preliminary results)

The combined T sub(1), T sub(2) and secular-T sub(2) pixel frequency distributions of 24 adult human brains were studied in vivo using a technique based on the mixed-TSE pulse sequence, dual-space clustering segmentation and histogram gaussian decomposition. Pixel frequency histograms of whole brain...

Full description

Saved in:
Bibliographic Details
Published in:Magnetic resonance imaging 2006-09, Vol.24 (7), p.877-887
Main Authors: Suzuki, Suzuko, Sakai, Osamu, Jara, Hernan
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 887
container_issue 7
container_start_page 877
container_title Magnetic resonance imaging
container_volume 24
creator Suzuki, Suzuko
Sakai, Osamu
Jara, Hernan
description The combined T sub(1), T sub(2) and secular-T sub(2) pixel frequency distributions of 24 adult human brains were studied in vivo using a technique based on the mixed-TSE pulse sequence, dual-space clustering segmentation and histogram gaussian decomposition. Pixel frequency histograms of whole brains and the four principal brain compartments were studied comparatively and as function of age. For white matter, the position of the T sub(1) peak correlates with age (R super(2)=.7868) when data are fitted to a quadratic polynomial. For gray matter, a weaker age correlation is found (R super(2)=.3687). T sub(2) and secular-T sub(2) results are indicative of a weaker correlation with age. The technique and preliminary results presented herein may be useful for characterizing normal as well as abnormal aging of the brain, and also for comparison with the results obtained with alternative quantitative MRI methodologies.
doi_str_mv 10.1016/j.mri.2006.04.011
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_17054358</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17054358</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_170543583</originalsourceid><addsrcrecordid>eNqNjLFOw0AQRK8AiUD4ALqtUCxhs2fHMaKNQKGgQSnSRWtn41x0vktu7yLxDfw0KSJqqhm9eRqlHjQWGvXseV8MwRQl4qzAaYFaX6kRNhXmTVmvbtStyB4R67KqR-pn7ofWON7Ayds0cAymgyVIaic6e7q0MgNyGxDukqWQ_8FjIhdNpGhODJ9fH-C3EHcMbSDjXoF6zgNbiuf33vqWLHQ7cj0LTA7nwQzGUfiGwJJslGysrrdkhe8veace39-W80V-CP6YWOJ6MNKxteTYJ1nrButpVb9U_xZ_AcPhWnE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17054358</pqid></control><display><type>article</type><title>Combined volumetric T sub(1), T sub(2) and secular-T sub(2) quantitative MRI of the brain: age-related global changes (preliminary results)</title><source>ScienceDirect Journals</source><creator>Suzuki, Suzuko ; Sakai, Osamu ; Jara, Hernan</creator><creatorcontrib>Suzuki, Suzuko ; Sakai, Osamu ; Jara, Hernan</creatorcontrib><description>The combined T sub(1), T sub(2) and secular-T sub(2) pixel frequency distributions of 24 adult human brains were studied in vivo using a technique based on the mixed-TSE pulse sequence, dual-space clustering segmentation and histogram gaussian decomposition. Pixel frequency histograms of whole brains and the four principal brain compartments were studied comparatively and as function of age. For white matter, the position of the T sub(1) peak correlates with age (R super(2)=.7868) when data are fitted to a quadratic polynomial. For gray matter, a weaker age correlation is found (R super(2)=.3687). T sub(2) and secular-T sub(2) results are indicative of a weaker correlation with age. The technique and preliminary results presented herein may be useful for characterizing normal as well as abnormal aging of the brain, and also for comparison with the results obtained with alternative quantitative MRI methodologies.</description><identifier>ISSN: 0730-725X</identifier><identifier>DOI: 10.1016/j.mri.2006.04.011</identifier><language>eng</language><ispartof>Magnetic resonance imaging, 2006-09, Vol.24 (7), p.877-887</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Suzuki, Suzuko</creatorcontrib><creatorcontrib>Sakai, Osamu</creatorcontrib><creatorcontrib>Jara, Hernan</creatorcontrib><title>Combined volumetric T sub(1), T sub(2) and secular-T sub(2) quantitative MRI of the brain: age-related global changes (preliminary results)</title><title>Magnetic resonance imaging</title><description>The combined T sub(1), T sub(2) and secular-T sub(2) pixel frequency distributions of 24 adult human brains were studied in vivo using a technique based on the mixed-TSE pulse sequence, dual-space clustering segmentation and histogram gaussian decomposition. Pixel frequency histograms of whole brains and the four principal brain compartments were studied comparatively and as function of age. For white matter, the position of the T sub(1) peak correlates with age (R super(2)=.7868) when data are fitted to a quadratic polynomial. For gray matter, a weaker age correlation is found (R super(2)=.3687). T sub(2) and secular-T sub(2) results are indicative of a weaker correlation with age. The technique and preliminary results presented herein may be useful for characterizing normal as well as abnormal aging of the brain, and also for comparison with the results obtained with alternative quantitative MRI methodologies.</description><issn>0730-725X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNjLFOw0AQRK8AiUD4ALqtUCxhs2fHMaKNQKGgQSnSRWtn41x0vktu7yLxDfw0KSJqqhm9eRqlHjQWGvXseV8MwRQl4qzAaYFaX6kRNhXmTVmvbtStyB4R67KqR-pn7ofWON7Ayds0cAymgyVIaic6e7q0MgNyGxDukqWQ_8FjIhdNpGhODJ9fH-C3EHcMbSDjXoF6zgNbiuf33vqWLHQ7cj0LTA7nwQzGUfiGwJJslGysrrdkhe8veace39-W80V-CP6YWOJ6MNKxteTYJ1nrButpVb9U_xZ_AcPhWnE</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Suzuki, Suzuko</creator><creator>Sakai, Osamu</creator><creator>Jara, Hernan</creator><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20060901</creationdate><title>Combined volumetric T sub(1), T sub(2) and secular-T sub(2) quantitative MRI of the brain: age-related global changes (preliminary results)</title><author>Suzuki, Suzuko ; Sakai, Osamu ; Jara, Hernan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_170543583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Suzuko</creatorcontrib><creatorcontrib>Sakai, Osamu</creatorcontrib><creatorcontrib>Jara, Hernan</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Suzuko</au><au>Sakai, Osamu</au><au>Jara, Hernan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined volumetric T sub(1), T sub(2) and secular-T sub(2) quantitative MRI of the brain: age-related global changes (preliminary results)</atitle><jtitle>Magnetic resonance imaging</jtitle><date>2006-09-01</date><risdate>2006</risdate><volume>24</volume><issue>7</issue><spage>877</spage><epage>887</epage><pages>877-887</pages><issn>0730-725X</issn><abstract>The combined T sub(1), T sub(2) and secular-T sub(2) pixel frequency distributions of 24 adult human brains were studied in vivo using a technique based on the mixed-TSE pulse sequence, dual-space clustering segmentation and histogram gaussian decomposition. Pixel frequency histograms of whole brains and the four principal brain compartments were studied comparatively and as function of age. For white matter, the position of the T sub(1) peak correlates with age (R super(2)=.7868) when data are fitted to a quadratic polynomial. For gray matter, a weaker age correlation is found (R super(2)=.3687). T sub(2) and secular-T sub(2) results are indicative of a weaker correlation with age. The technique and preliminary results presented herein may be useful for characterizing normal as well as abnormal aging of the brain, and also for comparison with the results obtained with alternative quantitative MRI methodologies.</abstract><doi>10.1016/j.mri.2006.04.011</doi></addata></record>
fulltext fulltext
identifier ISSN: 0730-725X
ispartof Magnetic resonance imaging, 2006-09, Vol.24 (7), p.877-887
issn 0730-725X
language eng
recordid cdi_proquest_miscellaneous_17054358
source ScienceDirect Journals
title Combined volumetric T sub(1), T sub(2) and secular-T sub(2) quantitative MRI of the brain: age-related global changes (preliminary results)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T18%3A48%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20volumetric%20T%20sub(1),%20T%20sub(2)%20and%20secular-T%20sub(2)%20quantitative%20MRI%20of%20the%20brain:%20age-related%20global%20changes%20(preliminary%20results)&rft.jtitle=Magnetic%20resonance%20imaging&rft.au=Suzuki,%20Suzuko&rft.date=2006-09-01&rft.volume=24&rft.issue=7&rft.spage=877&rft.epage=887&rft.pages=877-887&rft.issn=0730-725X&rft_id=info:doi/10.1016/j.mri.2006.04.011&rft_dat=%3Cproquest%3E17054358%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_170543583%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17054358&rft_id=info:pmid/&rfr_iscdi=true