Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition

•We tested the anti-hyperalgesic and anti-edematogenic effects of citronellol (CT).•CT is able to reduce the mechanical hyperalgesia and paw edema.•CT reduced the Fos activation on spinal cord lamina I.•We are suggesting the possible involvement of descending pain-inhibitory mechanisms in the analge...

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Published in:Chemico-biological interactions 2015-09, Vol.239, p.111-117
Main Authors: Brito, Renan G., dos Santos, Priscila L., Quintans, Jullyana S.S., de Lucca Júnior, Waldecy, Araújo, Adriano A.S., Saravanan, Shanmugam, Menezes, Irwin R.A., Coutinho, Henrique D.M., Quintans-Júnior, Lucindo J.
Format: Article
Language:English
Subjects:
Analgesics, Non-Narcotic - pharmacology
Animals
Citronellol
Dinoprostone - adverse effects
Edema - drug therapy
Fos
Hyperalgesia
Hyperalgesia - chemically induced
Hyperalgesia - drug therapy
Male
Mice
Monoterpenes
Monoterpenes - pharmacology
Pain
Spinal Cord
Spinal Cord Dorsal Horn - drug effects
Tumor Necrosis Factor-alpha - adverse effects
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Summary:•We tested the anti-hyperalgesic and anti-edematogenic effects of citronellol (CT).•CT is able to reduce the mechanical hyperalgesia and paw edema.•CT reduced the Fos activation on spinal cord lamina I.•We are suggesting the possible involvement of descending pain-inhibitory mechanisms in the analgesic effect of CT. We evaluated the anti-hyperalgesic effect of citronellol (CT) and investigated the spinal cord lamina I involvement in this effect. Male mice were pre-treated with CT (25, 50 and 100mg/kg, i.p.), indomethacin (10mg/kg, i.p.), dipyrone (60mg/kg, i.p.) or vehicle (saline+Tween 80 0.2%). Thirty minutes after the treatment, 20μL of carrageenan (CG; 300μg/paw), PGE2 (100ng/paw), dopamine (DA; 30μg/paw) or TNF-α (100pg/paw) were injected into the hind paw subplantar region and the mechanical threshold was evaluated with an electronic anesthesiometer. The CT effect on edema formation was evaluated after the right paw subplantar injection of CG (40μL; 1%) through the plethysmometer apparatus. To evaluate the CT action on the spinal cord, the animals were treated with CT (100mg/kg; i.p.) or vehicle (Saline+Tween 80 0.2%; i.p.) and, after 30min, 20μL of CG (300μg/paw; i.pl.) was injected. Ninety minutes after the treatment, the animals were perfused, the lumbar spinal cord collected, crioprotected, cut and submitted in an immunofluorescence protocol for Fos protein. CT administration produced a significantly reduction (p
ISSN:0009-2797
1872-7786
DOI:10.1016/j.cbi.2015.06.039