Diterpenes from rosemary ( Rosmarinus officinalis ): Defining their potential for anti-cancer activity

Highlights • Diterpenes from rosemary elicit a decrease of cell viability and proliferation. • Diterpenes are well absorbed and can achieve plasma concentrations that are physiologically relevant. • Rosemary extract is approved as a food preservative increasing the likelihood of human exposure to th...

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Bibliographic Details
Published in:Cancer letters 2015-10, Vol.367 (2), p.93-102
Main Authors: Petiwala, Sakina M, Johnson, Jeremy J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacokinetics
Antineoplastic Agents, Phytogenic - pharmacology
Apoptosis
Carnosic acid
Carnosol
Chemoprevention
Diterpenes - isolation & purification
Diterpenes - pharmacokinetics
Diterpenes - pharmacology
Diterpenes, Abietane - pharmacology
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Nrf2
Phytotherapy
Plant Extracts - isolation & purification
Plant Extracts - pharmacokinetics
Plant Extracts - pharmacology
Plants, Medicinal
Prostate cancer
Rodents
Rosemary
Rosmanol
Rosmarinus - chemistry
Signal Transduction - drug effects
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Summary:Highlights • Diterpenes from rosemary elicit a decrease of cell viability and proliferation. • Diterpenes are well absorbed and can achieve plasma concentrations that are physiologically relevant. • Rosemary extract is approved as a food preservative increasing the likelihood of human exposure to these phytochemicals.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.07.005