Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly from the diet or synthesized in the body from α-linolenic acid (ALA). Debate exists as to whether DHA synthesized from ALA can provide sufficient DHA for the adult brain, as measures of DHA synthesis from ingest...

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Bibliographic Details
Published in:Progress in lipid research 2015-07, Vol.59, p.54-66
Main Authors: Domenichiello, Anthony F., Kitson, Alex P., Bazinet, Richard P.
Format: Article
Language:English
Subjects:
ALA
Alpha-linolenic Acid
alpha-Linolenic Acid - metabolism
Animals
Biosynthetic Pathways
Brain
Brain - metabolism
DHA
Diet
Docosahexaenoic acid
Docosahexaenoic Acids - biosynthesis
Humans
Liver
Metabolism
Requirement
Synthesis
Uptake
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Summary:Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly from the diet or synthesized in the body from α-linolenic acid (ALA). Debate exists as to whether DHA synthesized from ALA can provide sufficient DHA for the adult brain, as measures of DHA synthesis from ingested ALA are typically
ISSN:0163-7827
1873-2194
DOI:10.1016/j.plipres.2015.04.002