Remote ischaemic preconditioning: is it a flag on the field?

Ischaemic preconditioning is one of several different techniques that have been proposed to render the heart more resistant to ischaemia/reperfusion injuries. A significant reduction of troponin release is ‘proof of concept’, however, whether ischaemic preconditioning leads to improved clinical outc...

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Bibliographic Details
Published in:Perfusion 2015-09, Vol.30 (6), p.438-447
Main Authors: Moscarelli, M, Angelini, GD, Suleiman, S, Fiorentino, F, Punjabi, PP
Format: Article
Language:English
Subjects:
Animals
Humans
Ischemic Preconditioning - methods
Reperfusion Injury - metabolism
Reperfusion Injury - prevention & control
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Summary:Ischaemic preconditioning is one of several different techniques that have been proposed to render the heart more resistant to ischaemia/reperfusion injuries. A significant reduction of troponin release is ‘proof of concept’, however, whether ischaemic preconditioning leads to improved clinical outcomes is still to be proven. Moreover, the exact mechanism of action still remains unknown since very few studies have investigated the signal transmission in humans.
ISSN:0267-6591
1477-111X
DOI:10.1177/0267659115570720