Severe non-pneumonic necrotising infections in children caused by Panton-Valentine leukocidin producing Staphylococcus aureus strains

Two cases of infection with Panton-Valentine Leukocidin (PVL) producing strains of Staphylococcus aureus are reported. A 15-year-old insulin dependent diabetic developed toxic shock syndrome and an abscess in the deep tissue around his left hip. A 34-day-old infant presented with a right orbital cel...

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Bibliographic Details
Published in:The Journal of infection 2005-06, Vol.50 (5), p.438-442
Main Authors: Reichert, B., Birrell, G., Bignardi, G.
Format: Article
Language:English
Subjects:
Abscess - diagnosis
Abscess - microbiology
Abscess - therapy
Adolescent
Anti-Bacterial Agents - therapeutic use
Bacterial diseases
Bacterial Toxins
Biological and medical sciences
Cellulitis - diagnosis
Cellulitis - microbiology
Exotoxins
Hip - pathology
Human bacterial diseases
Humans
Infant, Newborn
Infant, Premature
Infectious diseases
Leukocidins - metabolism
Magnetic Resonance Imaging
Male
Medical sciences
MRSA
Necrosis - diagnosis
Necrosis - microbiology
Necrosis - therapy
Orbital Diseases - diagnosis
Orbital Diseases - microbiology
Orbital Diseases - therapy
Panton-Valentine leukocidin
Soft Tissue Infections - diagnosis
Soft Tissue Infections - microbiology
Soft Tissue Infections - therapy
Staphylococcal Infections - diagnosis
Staphylococcal Infections - microbiology
Staphylococcal Infections - therapy
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus aureus - isolation & purification
Staphylococcus aureus - metabolism
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Summary:Two cases of infection with Panton-Valentine Leukocidin (PVL) producing strains of Staphylococcus aureus are reported. A 15-year-old insulin dependent diabetic developed toxic shock syndrome and an abscess in the deep tissue around his left hip. A 34-day-old infant presented with a right orbital cellulitis with an intra-orbital collection and septicaemia. In both cases PVL-producing strains of Staphylococcus aureus were isolated. Both surgery and prolonged antibiotic combination regimens were required to eradicate the infection. The cases reported here demonstrate the wide range of clinical presentations seen with PVL producing strains, which have so far been mainly associated with furuncles and necrotising pneumonia.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2004.08.007