Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue

Genomic structure, promoter region, amino acid sequence and exon-specific primer combinations of the human omentin gene are presented. Omentin mRNA expression differs between omental adipose tissue probes from patients with chronic inflammatory bowel diseases such as Crohn's disease. Sequence c...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2005-12, Vol.1732 (1), p.96-102
Main Authors: Schäffler, A., Neumeier, M., Herfarth, H., Fürst, A., Schölmerich, J., Büchler, C.
Format: Article
Language:English
Subjects:
Adipocyte
Adipose Tissue - metabolism
Adult
Amino Acid Sequence
Base Sequence
Binding Sites - genetics
Chronic inflammatory bowel disease
Crohn's disease
Cytokines - chemistry
Cytokines - genetics
Exons - genetics
Female
Genome, Human - genetics
Genomics
GPI-Linked Proteins
Humans
Hydrophobic and Hydrophilic Interactions
Intelectin
Lectins - chemistry
Lectins - genetics
Male
Middle Aged
Molecular Sequence Data
Omentin
Omentum - metabolism
Promoter Regions, Genetic - genetics
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:Genomic structure, promoter region, amino acid sequence and exon-specific primer combinations of the human omentin gene are presented. Omentin mRNA expression differs between omental adipose tissue probes from patients with chronic inflammatory bowel diseases such as Crohn's disease. Sequence comparisons revealed a 100% identity of omentin with human intelectin. Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/j.bbaexp.2005.11.005