Familial forms of multiple sclerosis and neuromyelitis optica at an MS center in Rio de Janeiro State, Brazil

Abstract Objective To describe familial forms of demyelinating diseases from an MS referral center in Río de Janeiro State, Brazil. Methods A descriptive, cross-sectional study was done to identify familial IIDD cases in Hospital da Lagoa, a public hospital where 75% of patients with IIDD who live i...

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Bibliographic Details
Published in:Journal of the neurological sciences 2015-09, Vol.356 (1), p.196-201
Main Authors: Papais-Alvarenga, Regina M, Pereira, Fernanda F.C. Costa, Bernardes, Melina S, Papais-Alvarenga, Marcos, Batista, Elizabeth, Paiva, Carmen A, Santos, Claudia Miranda, Vasconcelos, Claudia C.F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aquaporin-4
Brazil
Brazil - epidemiology
Concordance
Cross-Sectional Studies
Disability Evaluation
Familial form
Family Health
Female
Humans
Latin America
Magnetic Resonance Imaging
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - epidemiology
Neurologic Examination
Neurology
Neuromyelitis optica
Neuromyelitis Optica - epidemiology
NMO
NMO spectrum
Young Adult
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Summary:Abstract Objective To describe familial forms of demyelinating diseases from an MS referral center in Río de Janeiro State, Brazil. Methods A descriptive, cross-sectional study was done to identify familial IIDD cases in Hospital da Lagoa, a public hospital where 75% of patients with IIDD who live in Rio de Janeiro state, located in the Southeast region of Brazil, are referred. The diagnoses of all consecutive patients followed in 2011 were reviewed to apply new diagnostic criteria (Wingerchuk et al., 2008). The diagnosis of IIDD was confirmed based on clinical history, neurological examination, MRI of the skull and spinal cord, CSF analysis and investigation of IgG NMO antibodies. The cases that had at least one other relative with IIDD were selected for the study. Results Familial forms were found only in the multiple sclerosis (MS) and neuromyelitis optica syndrome (NMOSD) categories. 23 MS families were identified, 60.86% with first degree kinship. It has a Caucasian preponderance, 90% of whom were white. The frequency of early onset was 15% and 20% of the MSf cases have progressive primary course. Conclusion The frequency of familial cases of IIDD was 6.12% among MS patients and 2.8% in NMO spectrum syndromes.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2015.06.034