Palladium-Catalyzed Regioselective C–H Acylation of Biaryl-2-amines

A palladium-catalyzed efficient C–H acylation reaction of biaryl-2-amines and aromatic aldehydes is developed. This dehydrogenative cross-coupling protocol could furnish monoacylation and diacylation products in moderate to good yields with a broad substrate scope and good regioselectivity.

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Bibliographic Details
Published in:Journal of organic chemistry 2015-08, Vol.80 (16), p.7928-7936
Main Authors: Cai, Zhong-Jian, Yang, Chao, Wang, Shun-Yi, Ji, Shun-Jun
Format: Article
Language:English
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Summary:A palladium-catalyzed efficient C–H acylation reaction of biaryl-2-amines and aromatic aldehydes is developed. This dehydrogenative cross-coupling protocol could furnish monoacylation and diacylation products in moderate to good yields with a broad substrate scope and good regioselectivity.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b00962