Peripheral arterial disease in heterozygous familial hypercholesterolemia

Abstract Background Familial hypercholesterolemia is characterized by elevated plasma cholesterol and early coronary arterial disease onset. However, few studies investigated the association of heterozygous familial hypercholesterolemia with peripheral arterial disease. Methods In a cross sectional...

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Bibliographic Details
Published in:Atherosclerosis 2015-09, Vol.242 (1), p.174-178
Main Authors: Pereira, Carolina, Miname, Marcio H, Makdisse, Marcia R.P, Watanabe, Carolina, Pesaro, Antonio E, Jannes, Cinthia E, Kalil Filho, Roberto, Pereira, Alexandre C, Santos, Raul D
Format: Article
Language:English
Subjects:
Adult
Age Factors
Ankle Brachial Index
Atherosclerosis
Brazil - epidemiology
Cardiovascular
Case-Control Studies
Chi-Square Distribution
Comorbidity
Cross-Sectional Studies
Familial hypercholesterolemia
Female
Genetic Markers
Genetic Predisposition to Disease
Heterozygote
Humans
Hyperlipoproteinemia Type II - diagnosis
Hyperlipoproteinemia Type II - epidemiology
Hyperlipoproteinemia Type II - genetics
Logistic Models
Male
Middle Aged
Odds Ratio
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - epidemiology
Peripheral Arterial Disease - physiopathology
Peripheral artery disease
Prevalence
Propensity Score
Prospective Studies
Registries
Risk Assessment
Risk Factors
Smoking - adverse effects
Smoking - epidemiology
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Summary:Abstract Background Familial hypercholesterolemia is characterized by elevated plasma cholesterol and early coronary arterial disease onset. However, few studies investigated the association of heterozygous familial hypercholesterolemia with peripheral arterial disease. Methods In a cross sectional study 202 heterozygous familial hypercholesterolemia patients (91% confirmed by molecular diagnosis) were compared to 524 normolipidemic controls. Peripheral arterial disease was diagnosed by ankle-brachial index values ≤0.90. Results Compared with controls, familial hypercholesterolemia patients were older, more often female, with higher rates of hypertension, diabetes, previous coronary disease and higher total cholesterol levels. Smoking (previous and former) was more common among controls. The prevalence of peripheral arterial disease was 17.3 and 2.3% respectively in familial hypercholesterolemia and controls (p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.07.022