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Meta-analysis of dopamine receptor D1 rs4532 polymorphism and susceptibility to antipsychotic treatment response

Abstract Previous association results between dopamine D1 receptor (DRD1) rs4532 polymorphism and antipsychotic treatment response in schizophrenia and schizoaffective subjects have been conflicting. Thus, we have conducted a systematic review followed by a meta-analysis. Our results indicated no as...

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Published in:	Psychiatry research 2015-09, Vol.229 (1), p.586-588
Main Authors:	de Matos, Luiza P.R, Santana, Cinthia V.N, Souza, Renan P
Format:	Article
Language:	English
Subjects:	Antipsychotic Agents - therapeutic use Clozapine Clozapine - therapeutic use Female Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Humans Male Pharmacogenetics Pharmacogenomics Polymorphism, Single Nucleotide - genetics Psychiatry Receptors, Dopamine D1 - genetics Schizophrenia - drug therapy Schizophrenia - epidemiology Schizophrenia - genetics Treatment Outcome
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description	Abstract Previous association results between dopamine D1 receptor (DRD1) rs4532 polymorphism and antipsychotic treatment response in schizophrenia and schizoaffective subjects have been conflicting. Thus, we have conducted a systematic review followed by a meta-analysis. Our results indicated no association between DRD1 rs4532 polymorphism and overall antipsychotic response or clozapine monotherapy response.
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subjects	Antipsychotic Agents - therapeutic use Clozapine Clozapine - therapeutic use Female Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Humans Male Pharmacogenetics Pharmacogenomics Polymorphism, Single Nucleotide - genetics Psychiatry Receptors, Dopamine D1 - genetics Schizophrenia - drug therapy Schizophrenia - epidemiology Schizophrenia - genetics Treatment Outcome
title	Meta-analysis of dopamine receptor D1 rs4532 polymorphism and susceptibility to antipsychotic treatment response
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