Clinicopathological features of gastric adenocarcinoma patients with metachronous distant metastasis

Metachronous distant metastasis influences the postoperative survival of gastric adenocarcinoma patients with radical gastrectomy. We retrospectively reviewed 108 gastric adenocarcinoma patients with metachronous distant metastasis admitted to our hospital between January 2006 and December 2011. Fir...

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Bibliographic Details
Published in:Tumor biology 2015-08, Vol.36 (8), p.6375-6382
Main Authors: Bao, Junjie, Qu, Guofan, Fu, Wangshu, Li, Yanjing, Song, Haibin, Wei, Yuzhe, Xue, Yingwei
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Aged
Biomedical and Life Sciences
Biomedicine
Cancer Research
Female
Gastrectomy
Gastric cancer
Humans
Kaplan-Meier Estimate
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Medical prognosis
Metastasis
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Staging
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - pathology
Neoplasms, Second Primary - secondary
Neoplasms, Second Primary - surgery
Prognosis
Research Article
Retrospective Studies
Stomach Neoplasms - epidemiology
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
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Summary:Metachronous distant metastasis influences the postoperative survival of gastric adenocarcinoma patients with radical gastrectomy. We retrospectively reviewed 108 gastric adenocarcinoma patients with metachronous distant metastasis admitted to our hospital between January 2006 and December 2011. First, these patients were divided into two groups according to the time of metastasis: the early metastasis group (EMG) and late metastasis group (LMG). Second, according to the survival time after metastasis, these patients were divided into the longer survival group (LSG) and shorter survival group (SSG). Chi-square and Fisher exact tests were used to analyze associations between categorical variables. Survival data were estimated using the Kaplan–Meier method. Multivariate analyses of the prognostic factors related to overall survival were conducted using the Cox stepwise proportional hazards test. Results shows that the EMG was significantly associated with depth of invasion ( p  = 0.005), Union for International Cancer Control (UICC) stage ( p  = 0.003), degree of differentiation ( p  = 0.002), and vascular invasion ( p  = 0.001). The SSG was significantly associated with depth of invasion ( p  = 0.026) and normal carcinoembryonic antigen (CEA) level of after metastasis ( p  = 0.003). Survival analysis showed that depth of invasion ( p  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-015-3325-2