Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV

Unprotected receptive anal intercourse is a well-recognized risk factor for infection with human immunodeficiency virus-type 1 (HIV-1). Isolated human case reports have implicated HIV-1 transmission by oral-genital exposure. Adult macaques exposed nontraumatically to cell-free simian immunodeficienc...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-01, Vol.272 (5268), p.1486-1489
Main Authors: Baba, T W, Trichel, A M, An, Li, Lisda, V, Martin, L N, Murphey-Corb, M, Ruprecht, R M
Format: Article
Language:English
Subjects:
Macaca mulatta
simian immunodeficiency virus
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Summary:Unprotected receptive anal intercourse is a well-recognized risk factor for infection with human immunodeficiency virus-type 1 (HIV-1). Isolated human case reports have implicated HIV-1 transmission by oral-genital exposure. Adult macaques exposed nontraumatically to cell-free simian immunodeficiency virus (SIV) through the oral route became infected and developed acquired immunodeficiency syndrome (AIDS). The minimal virus dose needed to achieve systemic infection oral exposure was 6000 times lower than the minimal dose required to achieve systemic infection after rectal exposure. Thus, unprotected receptive oral intercourse, even in the absence of mucosal lesions, should be added to the list of risk behaviors for HIV-1 transmission.
ISSN:0036-8075