Mutagenic specificities and adduct distributions for 7-bromomethylbenz[a]anthracenes

Mutation induction in the supF gene of the plasmid pS189 by 7-bromomethylbenz[a]anthracene and 7-bromomethyl-12–7-bromomethylbenz[a]anthracene was examined. The former compound was substantially more mutagenic than the latter but a much greater proportion of the total mutations were located at mutat...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1996-02, Vol.17 (2), p.283-288
Main Authors: Page, John E., Ross, Helen L., Bigger, C.Anita H., Dipple, Anthony
Format: Article
Language:English
Subjects:
Base Sequence
Benz(a)Anthracenes - metabolism
Benz(a)Anthracenes - toxicity
Biological and medical sciences
Cell Line, Transformed
Chemical mutagenesis
Genes, Viral - drug effects
Genes, Viral - genetics
Genetic Vectors
Humans
Hydrocarbons, Brominated - toxicity
Medical sciences
Molecular Sequence Data
Mutagenicity Tests
Point Mutation
Toxicology
Viral Structural Proteins - genetics
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Summary:Mutation induction in the supF gene of the plasmid pS189 by 7-bromomethylbenz[a]anthracene and 7-bromomethyl-12–7-bromomethylbenz[a]anthracene was examined. The former compound was substantially more mutagenic than the latter but a much greater proportion of the total mutations were located at mutation hotspots for the 12-methyl derivative. The overall correlation between sites of mutation and sites of polymerase arrest (anindicator of adduct formation) through the supF gene was poor. Although these bromo-compounds should formonly a single guanine adduct (unlike dihydrodiol epoxides that from both cis and transadducts) more than one mutational change was found at a given site, although the predominant base substitution was G→for either compound.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/17.2.283