A new minor diketopiperazine from the sponge-derived fungus Simplicillium sp. YZ-11

Chemical investigation of the cultures of a sponge-derived fungus Simplicillium sp. YZ-11 led to the isolation of a new minor diketopiperazine alkaloid cyclo-(2-hydroxy-Pro-Gly) (1) and a natural lactone (S)-dihydro-5-[(S)- hydroxyphenylmethyl]-2(3H)-furanone (2), together with five known ergostane-...

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Bibliographic Details
Published in:Natural product research 2015-11, Vol.29 (21), p.2013-2017
Main Authors: Yan, Bing-Fei, Fang, Sheng-Tao, Li, Wen-Zuo, Liu, Su-Jing, Wang, Jian-Hua, Xia, Chuan-Hai
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - isolation & purification
Animals
Ascomycota - chemistry
cyclo-(2-hydroxy-Pro-Gly)
diketopiperazine
Diketopiperazines - chemistry
Diketopiperazines - isolation & purification
Fungi
Lactones - chemistry
Lactones - isolation & purification
marine sponge
Molecular Structure
NMR
Nuclear magnetic resonance
Optical properties
Optical rotation
Porifera - microbiology
Simplicillium sp
Sterols
Sterols - chemistry
Sterols - isolation & purification
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Summary:Chemical investigation of the cultures of a sponge-derived fungus Simplicillium sp. YZ-11 led to the isolation of a new minor diketopiperazine alkaloid cyclo-(2-hydroxy-Pro-Gly) (1) and a natural lactone (S)-dihydro-5-[(S)- hydroxyphenylmethyl]-2(3H)-furanone (2), together with five known ergostane-type sterols (3-7). Their structures were established based on extensive spectroscopic methods ( 1 H and 13 C NMR, 1 H- 1 H COSY, HSQC and HMBC) and optical rotation analysis.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2015.1027890