The Short-Term Effects of Ketogenic Diet on Cardiac Ventricular Functions in Epileptic Children

• Published in: Pediatric neurology 2015-09, Vol.53 (3), p.233-237.e1
• Main Authors: Doksöz, Önder, MD, Çeleğen, Kübra, MD, Güzel, Orkide, MD, Yılmaz, Ünsal, MD, Uysal, Utku, MD, İşgüder, Rana, MD, Çeleğen, Mehmet, MD, Meşe, Timur, MD
• Format: Article
• Language: English
• Subjects: cardiac function; Child, Preschool; children; Diet, Ketogenic; Drug Resistant Epilepsy - diet therapy; Drug Resistant Epilepsy - physiopathology; Electrocardiography; epilepsy; Female; Humans; ketogenic diet; Male; Neurology; Pediatrics; Prospective Studies; ventricular function; Ventricular Function - physiology
• ISSN: 0887-8994; 1873-5150
• DOI: 10.1016/j.pediatrneurol.2015.06.009

Abstract Objective Our primary aim was to determine the short-term effects of a ketogenic diet on cardiac ventricular function in patients with refractory epilepsy. Methods Thirty-eight drug-resistant epileptic patients who were treated with a ketogenic diet were enrolled in this prospective study. Echocardiography was performed on all patients before beginning the ketogenic diet and after the sixth month of therapy. Two-dimensional, M-mode, color flow, spectral Doppler, and pulsed-wave tissue Doppler imaging measurements were performed on all patients. Results The median age of the 32 patients was 45.5 months, and 22 (57.8%) of them were male. Body weight, height, and body mass index increased significantly at the sixth month of therapy when compared with baseline values ( P   0.05). Doppler flow indices of mitral annulus and tricuspid annulus velocity of patients at baseline and month 6 showed no significant differences ( P  > 0.05). Tricuspid annular E/A ratio was lower at month 6 ( P   0.05), there was a decrease in Ea velocity and Ea/Aa ratio gathered from tricuspid annulus at month 6 compared with baseline ( P