Identification of HLA-B56 variant (B560502) in the Korean population

:  We report here a new HLA‐B*56 allele, B*560502, identified by sequencing‐based typing in the Korean population. HLA‐B*560502 differs from B*560501 by a single nucleotide at position 141 in exon 2 (T(r)C). This single nucleotide substitution may not result in an amino acid difference in the α1 dom...

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Bibliographic Details
Published in:Tissue antigens 2004-04, Vol.63 (4), p.376-377
Main Authors: Pyo, C-W., Hur, S-S., Kim, D-W., Kim, C-C., Han, H., Kim, T-G.
Format: Article
Language:English
Subjects:
Alleles
B560501
B560502
Base Sequence
Exons - genetics
Haplotypes - genetics
HLA-B Antigens - genetics
Humans
Korea
Molecular Sequence Data
Point Mutation
Protein Structure, Tertiary - genetics
Sequence Alignment
sequence-based typing
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Summary::  We report here a new HLA‐B*56 allele, B*560502, identified by sequencing‐based typing in the Korean population. HLA‐B*560502 differs from B*560501 by a single nucleotide at position 141 in exon 2 (T(r)C). This single nucleotide substitution may not result in an amino acid difference in the α1 domain at residue 23. The putative haplotype involving B*560502 may be A*24‐DRB1*1201‐DQA1*0503‐DQB1*0304‐DPB1*0202.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.0001-2815.2004.00125.x