Dendrimer nanotechnology for enhanced formulation and controlled delivery of resveratrol

In spite of its wide and beneficial pharmacological potential, resveratrol lags behind other compounds because of its comparatively less impressive pharmacokinetic profile. Resveratrol has very low oral bioavailability and, from a formulation perspective, it has low solubility in water, which leads...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2015-08, Vol.1348 (1), p.134-140
Main Author: Chauhan, Abhay S.
Format: Article
Language:English
Subjects:
Animals
Aqueous solutions
Bioavailability
Biological Availability
Chemistry, Pharmaceutical
dendrimer
Dendrimers - administration & dosage
Dendrimers - chemistry
Dendrimers - pharmacokinetics
Drug Stability
Humans
PAMAM
resveratrol
Rodents
Solubility
Solutions
stability
Stilbenes - administration & dosage
Stilbenes - chemistry
Stilbenes - pharmacokinetics
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Summary:In spite of its wide and beneficial pharmacological potential, resveratrol lags behind other compounds because of its comparatively less impressive pharmacokinetic profile. Resveratrol has very low oral bioavailability and, from a formulation perspective, it has low solubility in water, which leads to its poor absorption upon oral administration. Apart from low aqueous solubility, resveratrol has poor metabolic stability and instability at high pH, and is photosensitive. The pharmacokinetic and formulation‐related limitations of resveratrol can be controlled by entrapping the small resveratrol molecule inside highly water‐soluble poly(amidoamine) dendrimer nanostructures, which provide spherical architecture and polyvalency at the nanoscale level, thus leading to novel features. Dendrimer architecture is used to entrap resveratrol for enhancement of its solubility and stability in aqueous solution; they can be engineered to control pharmacokinetics and targeting for oral, mucosal, transdermal, or parenteral administration. Dendrimers have the potential to work as excipients with multifunctional capability by enhancing solubility, dissolution, stability, permeability, multiple drug/cosmetic entrapment, controlled delivery, bioavailability, and efficacy of drugs.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.12816