Vitamin D receptor gene polymorphisms in Alzheimer's disease patients

• Published in: Experimental gerontology 2015-09, Vol.69, p.142-147
• Main Authors: Łaczmański, Łukasz, Jakubik, Marta, Bednarek-Tupikowska, Grażyna, Rymaszewska, Joanna, Słoka, Natalia, Lwow, Felicja
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - epidemiology; Alzheimer Disease - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Iran - epidemiology; Male; Middle Aged; Poland - epidemiology; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptors, Calcitriol - genetics; Turkey - epidemiology; United Kingdom - epidemiology; VDR polymorphism
• ISSN: 0531-5565; 1873-6815
• DOI: 10.1016/j.exger.2015.06.012

The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. 108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Silesian population were studied. We investigated the frequency of the VDR polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs10735810 (FokI) and rs1544410 (BsmI) in the AD group vs the healthy group. Afterwards, MEDLINE and ResearchGate were studied to compare our investigation with other populations, due to the relatively small group size in our study. We did not observe any significant differences in frequency of genotypes of rs731236 (TaqI), rs10735810 (FokI) or rs1544410 (BsmI) VDR polymorphisms between the two Lower Silesian groups. Frequency of allele A of ApaI in the control group was significantly higher vs AD patients (p