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Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. 108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Silesian pop...
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| Published in: | Experimental gerontology 2015-09, Vol.69, p.142-147 |
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| container_title | Experimental gerontology |
| container_volume | 69 |
| creator | Łaczmański, Łukasz Jakubik, Marta Bednarek-Tupikowska, Grażyna Rymaszewska, Joanna Słoka, Natalia Lwow, Felicja |
| description | The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations.
108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Silesian population were studied. We investigated the frequency of the VDR polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs10735810 (FokI) and rs1544410 (BsmI) in the AD group vs the healthy group. Afterwards, MEDLINE and ResearchGate were studied to compare our investigation with other populations, due to the relatively small group size in our study.
We did not observe any significant differences in frequency of genotypes of rs731236 (TaqI), rs10735810 (FokI) or rs1544410 (BsmI) VDR polymorphisms between the two Lower Silesian groups. Frequency of allele A of ApaI in the control group was significantly higher vs AD patients (p |
| doi_str_mv | 10.1016/j.exger.2015.06.012 |
| format | article |
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108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Silesian population were studied. We investigated the frequency of the VDR polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs10735810 (FokI) and rs1544410 (BsmI) in the AD group vs the healthy group. Afterwards, MEDLINE and ResearchGate were studied to compare our investigation with other populations, due to the relatively small group size in our study.
We did not observe any significant differences in frequency of genotypes of rs731236 (TaqI), rs10735810 (FokI) or rs1544410 (BsmI) VDR polymorphisms between the two Lower Silesian groups. Frequency of allele A of ApaI in the control group was significantly higher vs AD patients (p<0.0177) in the Lower Silesian population. Furthermore the difference in the occurrence of allele t in TaqI and allele A in ApaI between AD patients vs the control group was significant (respectively p<0.0056, p<0.0140) in British Europeans. This observation may suggest that allele “a” of the ApaI polymorphism is a risk allele in AD Lower Silesian patients. We compared our results with those obtained for the population of British Europeans. In multivariate stepwise regression, allele “A” of ApaI was associated with 30% lower risk of AD (OR=0.70, p=0.0009) in total treated Polish and British populations. We did not observe similar results in Turkish and Iranian populations.
Our data suggest that the allele “A” VDR genotype of ApaI reduces AD risk, probably depending on ethnic origin and climatic conditions.
•We describe the frequency of the VDR polymorphisms in AD vs a control group.•We summarize our investigations and refer to previously described data.•We used the meta-analysis method.•It is suggested that the rare VDR genotype increases AD risk.•It is depending on ethnic origin and climatic conditions.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2015.06.012</identifier><identifier>PMID: 26093050</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - epidemiology ; Alzheimer Disease - genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Iran - epidemiology ; Male ; Middle Aged ; Poland - epidemiology ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Receptors, Calcitriol - genetics ; Turkey - epidemiology ; United Kingdom - epidemiology ; VDR polymorphism</subject><ispartof>Experimental gerontology, 2015-09, Vol.69, p.142-147</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-31db54afd342e311a8ce133d647773e3fff2dda5141dcfd80f87a417b40a3cb3</citedby><cites>FETCH-LOGICAL-c359t-31db54afd342e311a8ce133d647773e3fff2dda5141dcfd80f87a417b40a3cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0531556515001904$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27901,27902,45756</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26093050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Łaczmański, Łukasz</creatorcontrib><creatorcontrib>Jakubik, Marta</creatorcontrib><creatorcontrib>Bednarek-Tupikowska, Grażyna</creatorcontrib><creatorcontrib>Rymaszewska, Joanna</creatorcontrib><creatorcontrib>Słoka, Natalia</creatorcontrib><creatorcontrib>Lwow, Felicja</creatorcontrib><title>Vitamin D receptor gene polymorphisms in Alzheimer's disease patients</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations.
108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Silesian population were studied. We investigated the frequency of the VDR polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs10735810 (FokI) and rs1544410 (BsmI) in the AD group vs the healthy group. Afterwards, MEDLINE and ResearchGate were studied to compare our investigation with other populations, due to the relatively small group size in our study.
We did not observe any significant differences in frequency of genotypes of rs731236 (TaqI), rs10735810 (FokI) or rs1544410 (BsmI) VDR polymorphisms between the two Lower Silesian groups. Frequency of allele A of ApaI in the control group was significantly higher vs AD patients (p<0.0177) in the Lower Silesian population. Furthermore the difference in the occurrence of allele t in TaqI and allele A in ApaI between AD patients vs the control group was significant (respectively p<0.0056, p<0.0140) in British Europeans. This observation may suggest that allele “a” of the ApaI polymorphism is a risk allele in AD Lower Silesian patients. We compared our results with those obtained for the population of British Europeans. In multivariate stepwise regression, allele “A” of ApaI was associated with 30% lower risk of AD (OR=0.70, p=0.0009) in total treated Polish and British populations. We did not observe similar results in Turkish and Iranian populations.
Our data suggest that the allele “A” VDR genotype of ApaI reduces AD risk, probably depending on ethnic origin and climatic conditions.
•We describe the frequency of the VDR polymorphisms in AD vs a control group.•We summarize our investigations and refer to previously described data.•We used the meta-analysis method.•It is suggested that the rare VDR genotype increases AD risk.•It is depending on ethnic origin and climatic conditions.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Poland - epidemiology</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Turkey - epidemiology</subject><subject>United Kingdom - epidemiology</subject><subject>VDR polymorphism</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EgvL4AiSUHWwSZuLYSRcsUHlKldggtpZrT1pXSRPsFFG-HkOBJavZnHuv5jB2ipAhoLxcZvQ-J5_lgCIDmQHmO2yEVclTWaHYZSMQHFMhpDhghyEsAUDmHPfZQS5hzEHAiN2-uEG3bpXcJJ4M9UPnkzmtKOm7ZtN2vl-40IYkAtfNx4JcS_48JNYF0iFCenC0GsIx26t1E-jk5x6x57vb58lDOn26f5xcT1PDxXhIOdqZKHRteZETR9SVIeTcyqIsS068ruvcWi2wQGtqW0FdlbrAclaA5mbGj9jFtrb33euawqBaFww1jV5Rtw4KS6hQ4hggonyLGt-F4KlWvXet9huFoL70qaX61qe-9CmQKuqLqbOfgfWsJfuX-fUVgastQPHLNxfjwUQDhqyL-gZlO_fvwCfl0oJA</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Łaczmański, Łukasz</creator><creator>Jakubik, Marta</creator><creator>Bednarek-Tupikowska, Grażyna</creator><creator>Rymaszewska, Joanna</creator><creator>Słoka, Natalia</creator><creator>Lwow, Felicja</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Vitamin D receptor gene polymorphisms in Alzheimer's disease patients</title><author>Łaczmański, Łukasz ; Jakubik, Marta ; Bednarek-Tupikowska, Grażyna ; Rymaszewska, Joanna ; Słoka, Natalia ; Lwow, Felicja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-31db54afd342e311a8ce133d647773e3fff2dda5141dcfd80f87a417b40a3cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Poland - epidemiology</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Turkey - epidemiology</topic><topic>United Kingdom - epidemiology</topic><topic>VDR polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Łaczmański, Łukasz</creatorcontrib><creatorcontrib>Jakubik, Marta</creatorcontrib><creatorcontrib>Bednarek-Tupikowska, Grażyna</creatorcontrib><creatorcontrib>Rymaszewska, Joanna</creatorcontrib><creatorcontrib>Słoka, Natalia</creatorcontrib><creatorcontrib>Lwow, Felicja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Łaczmański, Łukasz</au><au>Jakubik, Marta</au><au>Bednarek-Tupikowska, Grażyna</au><au>Rymaszewska, Joanna</au><au>Słoka, Natalia</au><au>Lwow, Felicja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D receptor gene polymorphisms in Alzheimer's disease patients</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>69</volume><spage>142</spage><epage>147</epage><pages>142-147</pages><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations.
108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Silesian population were studied. We investigated the frequency of the VDR polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs10735810 (FokI) and rs1544410 (BsmI) in the AD group vs the healthy group. Afterwards, MEDLINE and ResearchGate were studied to compare our investigation with other populations, due to the relatively small group size in our study.
We did not observe any significant differences in frequency of genotypes of rs731236 (TaqI), rs10735810 (FokI) or rs1544410 (BsmI) VDR polymorphisms between the two Lower Silesian groups. Frequency of allele A of ApaI in the control group was significantly higher vs AD patients (p<0.0177) in the Lower Silesian population. Furthermore the difference in the occurrence of allele t in TaqI and allele A in ApaI between AD patients vs the control group was significant (respectively p<0.0056, p<0.0140) in British Europeans. This observation may suggest that allele “a” of the ApaI polymorphism is a risk allele in AD Lower Silesian patients. We compared our results with those obtained for the population of British Europeans. In multivariate stepwise regression, allele “A” of ApaI was associated with 30% lower risk of AD (OR=0.70, p=0.0009) in total treated Polish and British populations. We did not observe similar results in Turkish and Iranian populations.
Our data suggest that the allele “A” VDR genotype of ApaI reduces AD risk, probably depending on ethnic origin and climatic conditions.
•We describe the frequency of the VDR polymorphisms in AD vs a control group.•We summarize our investigations and refer to previously described data.•We used the meta-analysis method.•It is suggested that the rare VDR genotype increases AD risk.•It is depending on ethnic origin and climatic conditions.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>26093050</pmid><doi>10.1016/j.exger.2015.06.012</doi><tpages>6</tpages></addata></record> |
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| ispartof | Experimental gerontology, 2015-09, Vol.69, p.142-147 |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - genetics Female Gene Frequency Genetic Predisposition to Disease Humans Iran - epidemiology Male Middle Aged Poland - epidemiology Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Receptors, Calcitriol - genetics Turkey - epidemiology United Kingdom - epidemiology VDR polymorphism |
| title | Vitamin D receptor gene polymorphisms in Alzheimer's disease patients |
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