Interleukin‐8‐producing primary cardiac undifferentiated sarcoma in a child with sustained fever

We report the case of a 12‐year‐old boy with primary undifferentiated sarcoma of the left atrium. He had sustained fever during the clinical course and multiple lung and brain metastases. Chemotherapy and irradiation were ineffective; he died 41 days after hospitalization. On retrospective analysis,...

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Bibliographic Details
Published in:Pediatrics international 2015-08, Vol.57 (4), p.742-745
Main Authors: Yanagisawa, Ryu, Nakamura, Tomohiko, Ogiso, Yoshifumi, Hachiya, Akira, Fujihara, Ikuko, Morita, Daisuke, Sakashita, Kazuo, Kitamura, Masatomo, Matsui, Hikoro, Nishijima, Fumie, Hayashi, Hidetaka, Hidaka, Eiko, Sano, Kenji, Shiohara, Masaaki, Yasukochi, Satoshi
Format: Article
Language:English
Subjects:
Cancer
Child
Cytokines
Diagnosis, Differential
Disease Progression
Echoencephalography
Fatal Outcome
Fever
Fever - etiology
Gene expression
Heart Atria - pathology
Heart Neoplasms - blood
Heart Neoplasms - pathology
Humans
Immunohistochemistry
Interleukin-8 - blood
Interleukin-8 - genetics
interleukin‐8
left atrium
Magnetic Resonance Spectroscopy
Male
metastasis
Pediatrics
primary cardiac tumor
Sarcoma - blood
Sarcoma - pathology
Tomography, X-Ray Computed
undifferentiated sarcoma
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Summary:We report the case of a 12‐year‐old boy with primary undifferentiated sarcoma of the left atrium. He had sustained fever during the clinical course and multiple lung and brain metastases. Chemotherapy and irradiation were ineffective; he died 41 days after hospitalization. On retrospective analysis, interleukin‐8 (IL‐8) was elevated; this was supported by immunohistochemistry and gene expression analysis of tumor samples. IL‐8 continued to increase with tumor progression accompanied by elevated neutrophil count and C‐reactive protein. IL‐8 is involved in malignant tumor proliferation, migration, and angiogenesis and may have been related to the clinical condition and prognosis in the present case.
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.12621