Pneumococcal vaccination reduced the risk of acute otitis media: Cohort study

Background Seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan. Methods From 10 daycare centers in...

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Bibliographic Details
Published in:Pediatrics international 2015-08, Vol.57 (4), p.582-585
Main Authors: Hasegawa, Junko, Mori, Mitsuru, Showa, Satoko, Matsushima, Aiko, Ohnishi, Hirofumi, Tsugawa, Takeshi, Yoto, Yuko, Tsutsumi, Hiroyuki
Format: Article
Language:English
Subjects:
Acute Disease
acute otitis media
Child
Child, Preschool
children
cohort study
Ear diseases
effectiveness
Female
Follow-Up Studies
Heptavalent Pneumococcal Conjugate Vaccine - pharmacology
Humans
Incidence
Infant
Japan - epidemiology
Male
Maternal & child health
Otitis Media - epidemiology
Otitis Media - microbiology
Otitis Media - prevention & control
Pediatrics
pneumococcal conjugate vaccine
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumonia
Prospective Studies
Retrospective Studies
Streptococcus pneumoniae - immunology
Vaccination - methods
Vaccines
Vaccines, Conjugate
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Summary:Background Seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan. Methods From 10 daycare centers in Sapporo, Japan, 614 parents participated in the survey. Each parent reported whether their child subject had received one or more doses of PCV7, and, if so, the exact dates of receiving PCV7 were verified by reviewing their maternal and child health handbooks marked by a pediatrician. AOM was diagnosed by otorhinolaryngologist or pediatrician. Cox's proportional hazard model was used for calculating the hazard ratio (HR) of AOM incidence reduced by PCV7 inoculation. Results Inoculation of PCV7 significantly reduced the risk of AOM (crude HR, 0.63; 95%CI: 0.50–0.79). Adjusting for potentially confounding variables reduced the risk further (adjusted HR, 0.32; 95%CI: 0.23–0.44). On stratification by subject age on 30 April 2012, PCV7 was significantly associated with a reduced risk of AOM in both infants
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.12587