Hepatic resection versus transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma with hepatic vein tumor thrombus

• Published in: Japanese journal of clinical oncology 2015-09, Vol.45 (9), p.837-843
• Main Authors: Zhang, Yong-Fa, Wei, Wei, Guo, Zhi-Xing, Wang, Jia-Hong, Shi, Ming, Guo, Rong-Ping
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - therapy; Case-Control Studies; Chemoembolization, Therapeutic; Female; Follow-Up Studies; Hepatectomy; Hepatic Veins; Humans; Liver Neoplasms - complications; Liver Neoplasms - mortality; Liver Neoplasms - therapy; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Portal Vein; Risk Factors; Survival Rate; Venous Thrombosis - complications
• ISSN: 0368-2811; 1465-3621
• DOI: 10.1093/jjco/hyv089

To compare the outcomes of hepatic resection and transcatheter arterial chemoembolization for resectable hepatocellular carcinoma with hepatic vein tumor thrombus. From January 2006 to November 2013, 28 patients initially diagnosed with resectable hepatocellular carcinoma combined with hepatic vein tumor thrombus received hepatic resection. These patients were compared with 56 case-matched controls (1:2 ratio) selected from a pool of 91 patients who received transcatheter arterial chemoembolization as an initial treatment during the same period. Clinical characteristics, adverse events, overall survival and survival-related factors were analyzed. The 1-, 2- and 3-year overall survival rates were 66.5, 37.4 and 28.5% for the hepatic resection group and 32.3, 18.7 and 15.6% for the transcatheter arterial chemoembolization group (P = 0.015), respectively. No significant difference was found between the two groups in terms of complications and mortality. Multivariate analyses revealed combined portal vein tumor thrombosis (HR = 2.116; 95% CI: 1.26-3.57; P = 0.005) and treatment allocation (hepatic resection = 2.289; 95% CI, 1.30-4.02; P = 0.004) as risk factors for overall survival. Hepatic resection provides a good prognosis for hepatocellular carcinoma patients with hepatic vein tumor thrombus compared with patients undergoing transcatheter arterial chemoembolization, and the most important factor related to survival was co-existence with portal vein invasion.