Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge

Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lip...

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Bibliographic Details
Published in:Infection and Immunity 2006-03, Vol.74 (3), p.1958-1961
Main Authors: Treviño, Sylvia R, Permenter, Amy R, England, Marilyn J, Parthasarathy, Narayanan, Gibbs, Paul H, Waag, David M, Chanh, Tran C
Format: Article
Language:English
Subjects:
Aerosols
Animals
Antibodies, Bacterial - administration & dosage
Antibodies, Bacterial - immunology
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - immunology
Applied microbiology
Bacteriology
Biological and medical sciences
Burkholderia mallei
Burkholderia mallei - immunology
Fundamental and applied biological sciences. Psychology
Glanders - immunology
Glanders - mortality
Glanders - prevention & control
Mice
Mice, Inbred BALB C
Microbial Immunity and Vaccines
Microbiology
Miscellaneous
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.74.3.1958-1961.2006