Potential programming of selected cardiometabolic risk factors at childhood by maternal polyunsaturated fatty acid availability in the MEFAB cohort

• Published in: Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2015-09, Vol.100, p.21-27
• Main Authors: Jochems, Sylvia H.J, Gielen, Marij, Rump, Patrick, Hornstra, Gerard, Zeegers, Maurice P
• Format: Article
• Language: English
• Subjects: Adult; Advanced Basic Science; Blood Pressure; Body Mass Index; Cardiometabolic disease risk; Cardiovascular Diseases - etiology; Child; Cohort Studies; Endocrinology & Metabolism; Fatty Acids, Essential - blood; Fatty Acids, Unsaturated - adverse effects; Fatty Acids, Unsaturated - blood; Female; Fetal origins; Glucose - metabolism; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Metabolic Diseases - etiology; Polyunsaturated fatty acids; Pregnancy; Prenatal programming; Risk Factors
• ISSN: 0952-3278; 1532-2823
• DOI: 10.1016/j.plefa.2015.06.001

Abstract Background Increasing evidence suggests that long-chain polyunsaturated fatty acid (LCPUFA) availability in utero could program later health. Objective The objective of the study was to explore whether prenatal LCPUFA availability could be involved in programming cardiometabolic disease risk at childhood. Methods Data of 242 mother–child pairs from the Maastricht Essential Fatty Acid Birth (MEFAB) cohort were used. Multi-variable linear regression analysis was applied to identify associations between maternal LCPUFA concentrations around weeks 11, 22 and 32 of pregnancy and at time of delivery and cardiometabolic risk factors of their children (glucose metabolism, blood lipids, and blood pressure) at age 7. Results Maternal eicosapentaenoic acid (20:5 n −3) at week 11 of pregnancy was negatively associated with children׳s glucose ( B =−0.34 mmol/L; 95% CI: −0.56, −0.12). Positive associations were found between maternal linoleic acid (18:2 n −6) at time of delivery and children׳s proinsulin ( B =0.25 pmol/L; 95% CI: 0.08, 0.41); maternal 3-docosapentaenoic acid (22:5 n −3) at week 11 and children׳s total cholesterol ( B =1.23 mmol/L; 95% CI: 0.45, 2.01) and low-density-lipoprotein cholesterol ( B =1.12 mmol/L; 95% CI: 0.42, 1.82); and maternal osbond acid (22:5 n −6) at week 22 and tetracosadienoic acid (24:2 n −6) at week 32 and children׳s diastolic blood pressure ( B =16.86 mmHg; 95% CI: 7.63, 26.08 and B =17.75 mmHg; 95% CI: 6.37, 29.94, respectively). Conclusion Our findings suggest that maternal omega-6 ( n −6) fatty acids may be of particular importance in relation to children׳s glucose metabolism and blood pressure, whereas omega-3 ( n −3) fatty acids seem particularly related to blood lipids at childhood. In general, the strength of the associations appeared stronger with fatty acid concentrations in early pregnancy compared to late pregnancy.